Morozov S, Batskikh S. Reactivation of hepatitis B virus infection – an important aspect of multifaceted problem. World J Gastroenterol 2024; 30(26): 3193-3197 [PMID: 39086636 DOI: 10.3748/wjg.v30.i26.3193]
Corresponding Author of This Article
Sergey Morozov, DSc, MD, PhD, Doctor, Senior Researcher, Department of Gastroenterology, Hepatology and Nutrition, Federal Research Center of Nutrition, Biotechnology and Food Safety, Kashirskoye Shosse 21, Moscow 115446, Russia. morosoffsv@mail.ru
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 14, 2024; 30(26): 3193-3197 Published online Jul 14, 2024. doi: 10.3748/wjg.v30.i26.3193
Reactivation of hepatitis B virus infection – an important aspect of multifaceted problem
Sergey Morozov, Sergey Batskikh
Sergey Morozov, Department of Gastroenterology, Hepatology and Nutrition, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow 115446, Russia
Sergey Batskikh, Department of Hepatology, Moscow Clinical Scientific Center N.A. A.S. Loginov, Moscow 111123, Russia
Author contributions: Morozov S and Batskikh S contributed to this paper; Morozov S and Batskikh S designed the overall concept and outline of the manuscript. All authors contributed to the discussion and design of the manuscript. All authors contributed to the writing, and editing the manuscript, illustrations, and review of literature.
Supported byMinistry of Science and Higher education of Russia, No. FGMF-2022-0005; and Moscow Healthcare Department, No. 123040700014-4.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sergey Morozov, DSc, MD, PhD, Doctor, Senior Researcher, Department of Gastroenterology, Hepatology and Nutrition, Federal Research Center of Nutrition, Biotechnology and Food Safety, Kashirskoye Shosse 21, Moscow 115446, Russia. morosoffsv@mail.ru
Received: March 14, 2024 Revised: May 28, 2024 Accepted: June 19, 2024 Published online: July 14, 2024 Processing time: 117 Days and 5 Hours
Abstract
In this editorial we comment on the article published in the recent issue of the World Journal of Gastroenterology. We focus specifically on the problem of occult hepatitis B virus (HBV) infection, that is a result of previous hepatitis B (PHB) and a source for reactivation of HBV. The prevalence of PHB is underestimated due to the lack of population testing programs. However, this condition not only complicate anticancer treatment, but may be responsible for the development of other diseases, like cancer or autoimmune disorders. Here we unveil possible mechanisms responsible for realization of these processes and suggest practical approaches for diagnosis and treatment.
Core Tip: Occult hepatitis B virus (HBV) infection is a result of previous hepatitis B (PHB) and source for reactivation of HBV. This may be a challenge when anti-cancer treatment is provided. However, PHB is a reason of other disorders, like cancer and autoimmune disorders development. We discuss this multifaceted problem from the viewpoint of pathogenetic mechanisms, and possible practical approaches.
