Zheng BH, Ni XJ, Liu HB. Exosomal microRNAs in hepatocellular carcinoma, expanding research field. World J Gastroenterol 2024; 30(20): 2618-2620 [PMID: 38855155 DOI: 10.3748/wjg.v30.i20.2618]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. May 28, 2024; 30(20): 2618-2620 Published online May 28, 2024. doi: 10.3748/wjg.v30.i20.2618
Exosomal microRNAs in hepatocellular carcinoma, expanding research field
Bo-Hao Zheng, Xiao-Jian Ni, Hou-Bao Liu
Bo-Hao Zheng, Xiao-Jian Ni, Hou-Bao Liu, Department of Biliary Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Bo-Hao Zheng, Xiao-Jian Ni, Hou-Bao Liu, Biliary Tract Disease Center of Zhongshan Hospital, Fudan University, Shanghai 200032, China
Bo-Hao Zheng, Xiao-Jian Ni, Hou-Bao Liu, Biliary Tract Disease Institute, Fudan University, Shanghai 200032, China
Bo-Hao Zheng, Xiao-Jian Ni, Hou-Bao Liu, Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Bo-Hao Zheng, Xiao-Jian Ni, Hou-Bao Liu, Shanghai Biliary Tract Minimal Invasive Surgery and Materials Engineering Research Center, Shanghai 200032, China
Author contributions: Zheng BH, Ni XJ, and Liu HB contributed to this paper; Liu HB designed the overall concept and outline of the manuscript; Ni XJ contributed to the discussion and design of the manuscript; Zheng BH and Ni XJ contributed to the writing, and editing the manuscript, illustrations, and review of the literature.
Supported bythe National Natural Science Foundation of China, No. 82303441; Natural Science Foundation of Shanghai Municipality, No. 21ZR1459100 and No. 22ZR1457900; Science and Technology Commission of Shanghai Municipality, No. 20DZ2254500; and Shanghai Anticancer Association EYAS Project.
Conflict-of-interest statement: All authors have nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: December 21, 2023 Revised: April 23, 2024 Accepted: May 10, 2024 Published online: May 28, 2024 Processing time: 158 Days and 1.2 Hours
Abstract
In this editorial we comment on the review by Wang et al published in the recent issue of the World Journal of Gastroenterology in 2023. Small extracellular vesicles (exosomes) play important roles in the tumor microenvironment. In this review, the authors introduce the following points: (1) The composition and function of exosomal microRNAs (miRNAs) of different cell origins in hepatocellular carcinoma (HCC); (2) the crosstalk between exosomal miRNAs from stromal cells and immune cells in the tumor microenvironment and the progression of HCC; and (3) the potential applicability of exosomal miRNAs derived from mesen-chymal stem cells in the treatment of HCC. In addition, the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC was introduced. In this review, the authors give us an overview of the exosomal RNA and summarize the function of exosomal RNA in HCC, which provides a deeper understanding of exosomal miRNAs to the readers.
Core Tip: This study summarized the origin of exosomal microRNAs (miRNAs) in hepatocellular carcinoma (HCC), the function of exosomal miRNAs in HCC, and the potential clinical implication in HCC, providing a better understanding of exosomal miRNAs in the progression of HCC patients.
