Inchingolo R, Cortese F, Pisani AR, Acquafredda F, Calbi R, Memeo R, Anagnostopoulos F, Spiliopoulos S. Selective internal radiation therapy segmentectomy: A new minimally invasive curative option for primary liver malignancies? World J Gastroenterol 2024; 30(18): 2379-2386 [PMID: 38764771 DOI: 10.3748/wjg.v30.i18.2379]
Corresponding Author of This Article
Riccardo Inchingolo, MD, Director, Doctor, Unit of Interventional Radiology, “F. Miulli” Regional General Hospital, Strada per Santeramo, Bari 70021, Italy. riccardoin@hotmail.it
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. May 14, 2024; 30(18): 2379-2386 Published online May 14, 2024. doi: 10.3748/wjg.v30.i18.2379
Selective internal radiation therapy segmentectomy: A new minimally invasive curative option for primary liver malignancies?
Riccardo Inchingolo, Francesco Cortese, Antonio Rosario Pisani, Fabrizio Acquafredda, Roberto Calbi, Riccardo Memeo, Fotis Anagnostopoulos, Stavros Spiliopoulos
Riccardo Inchingolo, Francesco Cortese, Fabrizio Acquafredda, Unit of Interventional Radiology, “F. Miulli” Regional General Hospital, Bari 70021, Italy
Antonio Rosario Pisani, Interdisciplinary Department of Medicine, Section of Nuclear Medicine, University of Bari “Aldo Moro”, Bari 70121, Italy
Roberto Calbi, Department of Radiology, General Regional Hospital “F. Miulli”, Acquaviva delle Fonti 70021, Italy
Riccardo Memeo, Unit of Hepato-Pancreatic-Biliary Surgery, “F. Miulli” Regional General Hospital, Bari 70021, Italy
Fotis Anagnostopoulos, Stavros Spiliopoulos, The Second Radiology Department, National and Kapodistrian University of Athens, Chaidari Athens 12461, Greece
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Riccardo Inchingolo, MD, Director, Doctor, Unit of Interventional Radiology, “F. Miulli” Regional General Hospital, Strada per Santeramo, Bari 70021, Italy. riccardoin@hotmail.it
Received: January 18, 2024 Revised: March 15, 2024 Accepted: April 19, 2024 Published online: May 14, 2024 Processing time: 114 Days and 5.5 Hours
Abstract
Transarterial radioembolization or selective internal radiation therapy (SIRT) has emerged as a minimally invasive approach for the treatment of tumors. This percutaneous technique involves the local, intra-arterial delivery of radioactive microspheres directly into the tumor. Historically employed as a palliative measure for liver malignancies, SIRT has gained traction over the past decade as a potential curative option, mirroring the increasing role of radiation segmentectomy. The latest update of the BCLC hepatocellular carcinoma guidelines recognizes SIRT as an effective treatment modality comparable to other local ablative methods, particularly well-suited for patients where surgical resection or ablation is not feasible. Radiation segmentectomy is a more selective approach, aiming to deliver high-dose radiation to one to three specific hepatic segments, while minimizing damage to surrounding healthy tissue. Future research efforts in radiation segmentectomy should prioritize optimizing radiation dosimetry and refining the technique for super-selective administration of radiospheres within the designated hepatic segments.
Core Tip: Transarterial radioembolization (TARE), with the concept of radiation segmentectomy, is undergoing a paradigm shift in its role in treating primary liver malignancies, particularly hepatocellular carcinoma. This editorial delves into the emerging applications of TARE and explores the rationale, technical aspects, and future perspectives in the field of radiation segmentectomy.
