Papp V, Miheller P. Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda. World J Gastroenterol 2024; 30(17): 2308-2310 [PMID: 38813049 DOI: 10.3748/wjg.v30.i17.2308]
Corresponding Author of This Article
Veronika Papp, MD, PhD, Adjunct Professor, Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 78 Üllői Street, Budapest 1082, Hungary. papp.veronika@semmelweis.hu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. May 7, 2024; 30(17): 2308-2310 Published online May 7, 2024. doi: 10.3748/wjg.v30.i17.2308
Chronic active and atrophic gastritis as significant contributing factor to the development of gastric cystica profunda
Veronika Papp, Pál Miheller
Veronika Papp, Pál Miheller, Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest 1082, Hungary
Author contributions: Papp V and Miheller P contributed equally to this work.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Veronika Papp, MD, PhD, Adjunct Professor, Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, 78 Üllői Street, Budapest 1082, Hungary. papp.veronika@semmelweis.hu
Received: February 18, 2024 Revised: March 20, 2024 Accepted: April 15, 2024 Published online: May 7, 2024 Processing time: 76 Days and 11.3 Hours
Abstract
Gastric cystica profunda (GCP) is an uncommon but underestimated gastric lesion. Its precancerous potential determines its significance. In addition to previous mucosa injury due to operations, biopsy or polypectomy, chronic active and atrophic gastritis may also lead to the development of GCPs. By carefully examining the stomach and taking biopsy samples from the susceptible regions, the stage of atrophy can be determined. Chronic atrophic gastritis is a risk factor for cancer evolvement and it can also contribute to GCPs formation. GCPs frequently occur close to early gastric cancers (EGCs) or EGC can arise from the cystic glands. Endoscopic resection is an effective and minimally invasive treatment in GCP.
Core Tip: Gastric cystica profunda (GCP) is a premalignant lesion developing on basis of ischemia. Chronic active or atrophic gastritis are considered to be a significant etiological factors in the development of GCPs and carry a risk for cancer formation. GCPs, with or without early gastric cancer, can be removed effectively by endoscopic resection.
