Wang ZY, Qu YF, Yu TM, Liu ZL, Cheng YG, Zhong MW, Hu SY. Novel subtype of obesity influencing the outcomes of sleeve gastrectomy: Familial aggregation of obesity. World J Gastroenterol 2024; 30(13): 1887-1898 [PMID: 38659480 DOI: 10.3748/wjg.v30.i13.1887]
Corresponding Author of This Article
Ming-Wei Zhong, MD, Professor, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, No. 16766, Jingshi Road, Jinan 250000, Shandong Province, China. zmwgz@126.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ze-Yu Wang, Yun-Fei Qu, Zeng-Lin Liu, Yu-Gang Cheng, Ming-Wei Zhong, San-Yuan Hu, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan 250000, Shandong Province, China
Ze-Yu Wang, Yun-Fei Qu, Department of Postgraduate, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250000, Shandong Province, China
Tian-Ming Yu, Zeng-Lin Liu, Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine Shandong University, Jinan 250000, Shandong Province, China
Ming-Wei Zhong, State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, Shandong Province, China
Author contributions: Wang ZY designed and performed the research and wrote the paper; Hu SY and Zhong MW designed the research and supervised the report; Qu YF contributed to the analysis; Yu TM and Liu ZL provided clinical advice; and Cheng YG supervised the report.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital (Approval No. S447).
Informed consent statement: All personal information was encrypted and all data were anonymous. Therefore, informed consent of all study subjects is waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Wei Zhong, MD, Professor, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, No. 16766, Jingshi Road, Jinan 250000, Shandong Province, China. zmwgz@126.com
Received: January 12, 2024 Peer-review started: January 12, 2024 First decision: January 30, 2024 Revised: February 7, 2024 Accepted: March 14, 2024 Article in press: March 14, 2024 Published online: April 7, 2024 Processing time: 82 Days and 3.8 Hours
Abstract
BACKGROUND
Differences in the preoperative characteristics and weight loss outcomes after sleeve gastrectomy (SG) between patients with familial aggregation of obesity (FAO) and patients with sporadic obesity (SO) have not been elucidated.
AIM
To explore the impact of SG on weight loss and the alleviation of obesity-related comorbidities in individuals with FAO.
METHODS
A total of 193 patients with obesity who underwent SG were selected. Patients with FAO/SO were matched 1:1 by propensity score matching and were categorized into 4 groups based on the number of first-degree relatives with obesity (1SO vs1FAO, 2SO vs2FAO). The baseline characteristics, weight loss outcomes, prevalence of obesity-related comorbidities and incidence of major surgery-related complications were compared between groups.
RESULTS
We defined FAO as the presence of two or more first-degree relatives with obesity. Patients with FAO did not initially show significant differences in baseline data, short-term postoperative weight loss, or obesity-related comorbidities when compared to patients with SO preoperatively. However, distinctions between the two groups became evident at the two-year mark, with statistically significant differences in both percentage of total weight loss (P = 0.006) and percentage of excess weight loss (P < 0.001). The FAO group exhibited weaker remission of type 2 diabetes mellitus (T2DM) (P = 0.031), hyperlipidemia (P = 0.012), and non-alcoholic fatty liver disease (NAFLD) (P = 0.003) as well as a lower incidence of acid reflux (P = 0.038).
CONCLUSION
FAO patients is associated with decreased mid-to-long-term weight loss outcomes; the alleviation of T2DM, hyperlipidemia and NAFLD; and decreased incidence of acid reflux postoperatively.
Core Tip: This was a retrospective study. We aimed to compare preoperative characteristics and postoperative outcomes between patients with familial aggregation of obesity (FAO) and those with sporadic obesity. The following data were examined: Baseline characteristics, weight changes at postoperative intervals (1, 3, 6, 12, 24, and 36 months), alleviation of obesity-related complications, and the occurrence of surgery-related complications. Such a comparative analysis provides valuable insights for guiding postoperative treatment and health education tailored to individuals with FAO.
