Boscarelli A, Bramuzzo M. Pediatric stricturing Crohn's disease. World J Gastroenterol 2024; 30(12): 1651-1654 [PMID: 38617744 DOI: 10.3748/wjg.v30.i12.1651]
Corresponding Author of This Article
Alessandro Boscarelli, MD, Surgeon, Department of Pediatric Surgery and Urology, Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Via dell'Istria, 65/1, Trieste 34137, Italy. alessandro.boscarelli@burlo.trieste.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Mar 28, 2024; 30(12): 1651-1654 Published online Mar 28, 2024. doi: 10.3748/wjg.v30.i12.1651
Pediatric stricturing Crohn's disease
Alessandro Boscarelli, Matteo Bramuzzo
Alessandro Boscarelli, Department of Pediatric Surgery and Urology, Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Trieste 34137, Italy
Matteo Bramuzzo, Department of Gastrointestinal Endoscopy and Nutrition, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste 34137, Italy
Author contributions: Boscarelli A wrote the first draft of the manuscript; Boscarelli A and Bramuzzo M reviewed and revised the final manuscript. All authors listed on the manuscript have seen and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alessandro Boscarelli, MD, Surgeon, Department of Pediatric Surgery and Urology, Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”, Via dell'Istria, 65/1, Trieste 34137, Italy. alessandro.boscarelli@burlo.trieste.it
Received: December 25, 2023 Peer-review started: December 25, 2023 First decision: January 27, 2024 Revised: January 31, 2024 Accepted: March 6, 2024 Article in press: March 6, 2024 Published online: March 28, 2024 Processing time: 94 Days and 0.8 Hours
Abstract
Crohn’s disease (CD) is a chronic inflammatory disease of the digestive tract. The incidence of pediatric CD is increasing and is currently 2.5–11.4 per 100000 world-wide. Notably, approximately 25% of children with CD develop stricturing CD (SCD) that requires intervention. Symptomatic stricturing diseases refractory to pharmacological management frequently require non-pharmacological interventions. Non-pharmacological therapeutic strategies include endoscopic balloon dilatation, stricturoplasty, and surgical resection of the strictured segment. However, strictures tend to recur postoperatively regardless of treatment modality. The lifetime risk of surgery in patients with childhood SCD remains at 50%–90%. Thus, new and emerging strategies, advanced diagnostic tools, and minimally invasive approaches are under investigation to improve the outcomes and overall quality of life of pediatric patients with SCD.
Core Tip: Crohn’s disease (CD) is a chronic inflammatory disease of the digestive tract, and approximately one out of four children develop stricturing CD (SCD) requiring intervention. Since strictures tend to recur postoperatively regardless of treatment modality and the estimated lifetime risk of surgery in patients with childhood SCD remains high, new emerging strategies may help to improve the outcomes and overall quality of life of patients with SCD.
