Immunohistochemical study of gastrin in colorectal carcinoma tissues and adjacent mucosa

doi:10.3748/wjg.v3.i2.84

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Jun 15, 1997 (publication date) through Nov 9, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 1997; 3(2): 84-86
Published online Jun 15, 1997. doi: 10.3748/wjg.v3.i2.84

Immunohistochemical study of gastrin in colorectal carcinoma tissues and adjacent mucosa

Chun-Ping Jiang, Yu-Quan Chen, Jian-Wei Zhu, Hong-Xun Shen, Xiu Yu

Chun-Ping Jiang, Yu-Quan Chen, Jian-Wei Zhu, Hong-Xun Shen, Xiu Yu, Department of General Surgery, Affiliated Hospital, Nantong Medical College, Nantong 226001, Jiangsu Province, China

Chun-Ping Jiang, has published 12 papers.

Author contributions: All authors contributed equally to the work.

Supported by The Youth Science Foundation of Jiangsu Province, China, No. Q9202.

Correspondence to: Dr. Chun-Ping Jiang, Department of General Surgery, Affiliated Hospital, Nantong Medical College, Nantong 226001, Jiangsu Province, China

Telephone: +86-513-5513161-352

Received: July 4, 1996
Revised: November 14, 1996
Accepted: March 1, 1997
Published online: June 15, 1997

Abstract

AIM: To study gastrin expression in colorectal carcinoma tissues and adjacent mucosa and discuss the function of gastrin in colorectal carcinoma.

METHODS: Gastrin expression in colorectal carcinoma tissues and adjacent mucosa was examined in 58 cases using immunohistochemical and immunoelectron microscopy.

RESULTS: A total of 35.1% of colorectal carcinoma transitional mucosa (TM), 48.3% of nontypical dysplasia mucosa and 60.3% of carcinoma tissue were positive for gastrin expression (P < 0.05). Immunoelectron microscopy revealed that protein A gold (PAG) granules localized to different electron-dense secretory granules in carcinoma cells, the intercellular spaces, and the microvillar membrane surface.

CONCLUSION: Gastrin expression in colorectal carcinoma tissue and adjacent mucosa, and the release of gastrin by carcinoma may be an initiating factor in carcinoma occurrence and development. Positive gastrin expression in colorectal carcinoma tissues can serve as a differentiation marker.

Keywords: Colorectal neoplasms; Gastrin; Immunohistochemistry; microscopy; Electron