Huang ZH, Yang DZ, Wei YQ, Luo YH. Effect of muscarinic blocker on enhancing the action of fructus aurantii immaturus on intestinal myoelectric activity in dogs. World J Gastroenterol 1997; 3(2): 127-128 [PMID: 27041972 DOI: 10.3748/wjg.v3.i2.127]
Corresponding Author of This Article
Zi-He Huang, Second Affiliated Hospital of Shantou University Medical College, Shantou 515031, Guangdong Province, China
Article-Type of This Article
Original Research
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World J Gastroenterol. Jun 15, 1997; 3(2): 127-128 Published online Jun 15, 1997. doi: 10.3748/wjg.v3.i2.127
Effect of muscarinic blocker on enhancing the action of fructus aurantii immaturus on intestinal myoelectric activity in dogs
Zi-He Huang, De-Zhi Yang, Yi-Quan Wei, Yin-Hui Luo
Zi-He Huang, Yin-Hui Luo, Second Affiliated Hospital of Shantou University Medical College, Shantou 515031, Guangdong Province, China
De-Zhi Yang, Yi-Quan Wei, Physiology Department of Nanjing Railway Medical College , Shantou 515031, Guangdong Province, China
Zi-He Huang, female, born on April 14, 1956, graduated from the Medical Department, Shanghai Medical University in 1982. Lecturer of electrophysiology, engaged in clinical electrophysiological testing, has published 9 papers
Author contributions: All authors contributed equally to the work.
Supported by The National Natural Science Foundation of China, No. 3870577.
Correspondence to: Zi-He Huang, Second Affiliated Hospital of Shantou University Medical College, Shantou 515031, Guangdong Province, China
Telephone: +86-754-8565185
Received: October 11, 1996 Revised: January 31, 1997 Accepted: March 1, 1997 Published online: June 15, 1997
Abstract
AIM: To investigate the effect of fructus aurantii immaturus (FAI) on small intestinal electrical activity in dogs.
METHODS: The effect of FAI was observed using a computerized electrophysiological method with the migrating myoelectric complex as a criterion. Fasted, healthy, and conscious dogs were given 100% FAI concentrated solution by gastrostogavage, and as soon as the effect on small intestinal electrical activity appeared, atropine was injected intramuscularly.
RESULTS: The enhancing action of FAI was inhibited significantly by atropine, a cholinergic receptor antagonist. Both the number of spike bursts per cluster and the number of spikes per minute in phase II and III and the general cycle were decreased (P < 0.01), although the duration of phase II and the general cycle was prolonged.
CONCLUSION: The effect of FAI might be related to the muscarinic receptors.
