Zhao P, Yu YC, Wang DW, Wang ZP, Xu XZ, Yi PY, Gao YB, Yang GH. Relationship between loss of heterozygosity of deleted in colorectal carcinoma gene microsatellites and prognosis of colorectal adenocarcinoma. World J Gastroenterol 1997; 3(2): 121-122 [PMID: 27041969 DOI: 10.3748/wjg.v3.i2.121]
Corresponding Author of This Article
Dr. Po Zhao, MD and PhD, Associate Professor, Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China
Article-Type of This Article
Original Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 15, 1997; 3(2): 121-122 Published online Jun 15, 1997. doi: 10.3748/wjg.v3.i2.121
Relationship between loss of heterozygosity of deleted in colorectal carcinoma gene microsatellites and prognosis of colorectal adenocarcinoma
Po Zhao, Ying-Chuan Yu, De-Wen Wang, Zhi-Ping Wang, Xin-Zhao Xu, Ping-Yong Yi, Ya-Bing Gao, Guang-Hua Yang
Po Zhao, Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China
Ying-Chuan Yu, Ping-Yong Yi, Guang-Hua Yang, Department of Pathology, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China
De-Wen Wang, Zhi-Ping Wang, Ya-Bing Gao, Department of Pathology, Academy of Military Medical Sciences, Beijing 100850, China
Xin-Zhao Xu, Department of Pathology, General Hospital of Chinese PLA, Jinan Command Area
Po Zhao, MD and PhD, Associate Professor of Pathology, Head of Molecular Pathology Lab, has published 40 papers.
Author contributions: All authors contributed equally to the work.
Supported by The Scientific Foundation for Chinese Postdoctorates, No. 1994-3.
Correspondence to: Dr. Po Zhao, MD and PhD, Associate Professor, Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China
Telephone: +86-10-66887329-6253
Received: October 25, 1996 Revised: January 31, 1997 Accepted: March 1, 1997 Published online: June 15, 1997
Abstract
AIM: To investigate the relationship between the loss of heterozygosity (LOH) of microsatellites on the deleted in colorectal carcinoma (DCC) gene and prognosis of colorectal adenocarcinoma.
METHODS: A retrospective study of 58 colorectal adenocarcinoma cases with follow-up data and paired control normal mucosal tissues from 1983 to 1985 from files from the West China University of Medical Sciences Department of Pathology was carried out by PCR microsatellite analysis. Sixteen, 35, and seven cases had well-, moderately, and poorly differentiated tumors, respectively; 11, 30, and 17 cases were staged as Dukes’ A, B, and C, respectively.
RESULTS: LOH of DCC microsatellites was detected in 18 cases (31.0%). The 5-year survival rate between LOH-positive and LOH-negative patients was 44.4% and 77.5%, respectively (P < 0.05). The results suggest that LOH of DCC microsatellites correlate with prognosis but not with differentiation (P > 0.05) and Dukes’ stage (P > 0.05) in colorectal adenocarcinoma.
CONCLUSION: LOH of DCC microsatellites may be a marker of malignancy. Combined with the traditional prognostic indicators, LOH can predict prognosis of colorectal adenocarcinoma.
