Sun DG, Liu CY, Meng ZD, Sun YD, Wang SC, Yang YQ, Liang ZL, Zhuang H. A prospective study of vertical transmission of hepatitis C virus. World J Gastroenterol 1997; 3(2): 111-113 [PMID: 27041962 DOI: 10.3748/wjg.v3.i2.111]
Corresponding Author of This Article
Dr. De-Gui Sun, Guan County Sanitary and Antiepidemic Station, Guan County 065500, Hebei Province, China
Article-Type of This Article
Original Research
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De-Gui Sun, Cai-Yun Liu, Shu-Cong Wang, Yu-Qi Yang, Guan County Sanitary and Antiepidemic Station, Guan County 065500, Hebei Province, China
Zong-Da Meng, Yong-De Sun, Hebei Provincial Sanitary and Antiepidemic Station, Guan County 065500, Hebei Province, China
Zheng-Lun Liang, Hui Zhuang, Beijing Medical University, Beijing 100000, China
De-Gui Sun, male, born on June 1, 1953, in Guan County, Hebei Province, graduated from Langfang Health School, Associate Professor, specialized in the prevention of viral hepatitis, with 27 papers published
Author contributions: All authors contributed equally to the work.
Supported by The Hebei Scientific Foundation, No. 91021701, and the National “8th Five Year” Research Project.
Correspondence to: Dr. De-Gui Sun, Guan County Sanitary and Antiepidemic Station, Guan County 065500, Hebei Province, China
Telephone: +86-316-6362937
Received: September 20, 1996 Revised: January 31, 1997 Accepted: March 1, 1997 Published online: June 15, 1997
Abstract
AIM: To prospectively study the mechanism of mother to infant transmission of hepatitis C virus (HCV).
METHODS: Using a nested PCR for detection of HCV RNA and the second generation ELISA for detection of anti-HCV, 13 pregnant women who suffered from post transfusion hepatitis C (PT-HCV) and their 15 babies were studied to evaluate mother to infant transmission of HCV.
RESULTS: The total infection rate of HCV was 86.7% in the babies, including one case of clinical HCV (7.7%), three subclinical cases of HCV (23.1%), and nine inapparent cases of HCV (69.2%). The positive rates of anti-HCV and HCV RNA declined with the age of the babies, to 7.7% for anti-HCV and 15.4% for HCV RNA at the age of three years.
CONCLUSION: Babies born to mothers infected with HCV were vertically infected with HCV at a high rate, but the consequences were not serious. Four fetuses born, born through induced labor to mothers positive for anti-HCV and HCV, were all infected by HCV, suggesting that the mother to infant transmission of HCV mainly occurred in the uterus.
