Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2023; 29(44): 5935-5944
Published online Nov 28, 2023. doi: 10.3748/wjg.v29.i44.5935
Mucosal esophageal carcinoma following endoscopic submucosal dissection with giant gastric metastasis: A case report and review of literature
Mei-Qi Yang, Ming-Jun Sun, Hui-Jing Zhang
Mei-Qi Yang, Hui-Jing Zhang, Department of Gastroenterology, The First Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
Ming-Jun Sun, Department of Endoscopy, The First Affiliated Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
Co-corresponding authors: Sun MJ and Zhang HJ.
Author contributions: Zhang HJ and Sun MJ had full access to all the content in the study and takes responsibility for the integrity and the accuracy of the data analysis; Yang MQ and Sun MJ performed information collection; Yang MQ and Zhang HJ wrote the paper and performed editing. Sun MJ and Zhang HJ contributed equally to this work as co-corresponding authors. The reasons for designating Sun MJ and Zhang HJ as co-corresponding authors are threefold. Firstly, our research project is a collaborative effort. Throughout the entire research process, we worked closely together, sharing responsibilities in experimental design, data analysis, and result interpretation. Each of us made significant contributions in different aspects, whether it be in experimental operations, data processing, or writing and revising the manuscript. Therefore, we believe that designating two corresponding authors accurately reflects our collective efforts and academic contributions. Secondly, the selection of two corresponding authors is also driven by our commitment to academic fairness and transparency. This also promotes the most comprehensive and in-depth examination of the research topic, ultimately enriching readers' understanding by offering various expert perspectives. Thirdly, Sun MJ and Zhang HJ contributed efforts of equal substance throughout the research process. Sun MJ made a significant contribution to the diagnostic process of this case. The choice of these researchers as co-corresponding authors acknowledges and respects this equal contribution, while recognizing the spirit of teamwork and collaboration of this study. In summary, we believe that designating Sun MJ and Zhang HJ as co-corresponding authors of is fitting for our manuscript as it accurately reflects our team's collaborative spirit, equal contributions, and diversity.
Supported by Natural Science Foundation of Liaoning Science, No. 2022-YGJC-71.
Informed consent statement: All procedures involving human participants performed in this study were in accordance with the ethical standards of the institutional and/or national research committee(s) and the Helsinki Declaration (as revised in 2013). Written informed consent was obtained from all patients.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui-Jing Zhang, PhD, Professor, Department of Gastroenterology, The First Hospital of China Medical University, No. 155 Beier Road, Nanjing Street, Shenyang 110000, Liaoning Province, China. hjzhang@cmu.edu.cn
Received: September 19, 2023
Peer-review started: September 19, 2023
First decision: October 8, 2023
Revised: October 15, 2023
Accepted: November 14, 2023
Article in press: November 14, 2023
Published online: November 28, 2023
Processing time: 68 Days and 5.5 Hours
Abstract
BACKGROUND

Esophageal carcinoma is a highly aggressive digestive cancer responsible for a notable proportion of cancer-related deaths worldwide. Its elevated metastatic rate contributes to a poor prognosis in affected patients. In this case review, we aim to summarize the metastatic characteristics of intramural gastric metastasis (IGM) in mucosal esophageal squamous carcinoma.

CASE SUMMARY

A 56-year-old man was admitted to our hospital because of a dry cough with an esophageal sensation for one year. Endoscopic examination revealed a 2.0 cm 1.0 cm, superficial esophageal squamous cell carcinoma, and the patient underwent endoscopic submucosal dissection (ESD). Fifteen months after ESD, positron emission tomography/computed tomography revealed that the metabolism of the stomach cardia wall had increased slightly. However, the mucosa of the gastric cardia was smooth under gastroendoscopy. Two years after ESD, endoscopic examination revealed a giant gastric cardia carcinoma, while the esophageal mucosa was smooth, and no advanced cancer was found. A biopsy of the gastric cardia indicated squamous-cell carcinoma. The patient received immunochemotherapy and radiotherapy for esophageal cancer for 8 mo and is currently under follow-up.

CONCLUSION

Early-stage esophageal carcinoma with IGM is rare. Despite the ESD of the primary lesion, IGM may still occur and should be closely monitored after ESD.

Keywords: Esophageal squamous cell carcinoma; Intramural metastasis; Endoscopic submucosal dissection; Case report

Core Tip: This study presents a rare case of mucosal esophageal squamous cell carcinoma (ESCC) post endoscopic submucosal dissection with giant gastric cardia metastasis. intramural gastric metastasis has also been reported to plays a role in distant metastasis, particularly in the liver. Preoperative and postoperative endoscopic follow-up of patients with ESCC of any stage, although the depth of an esophageal cancer may be T1.