Published online Sep 7, 2023. doi: 10.3748/wjg.v29.i33.5005
Peer-review started: June 14, 2023
First decision: August 5, 2023
Revised: August 7, 2023
Accepted: August 15, 2023
Article in press: August 15, 2023
Published online: September 7, 2023
Processing time: 78 Days and 17.8 Hours
Although endoscope-assisted magnetic compression anastomosis has already been reported for colonic anastomosis, there is no report on a single-approach operation using the natural orifice.
To design a deformable self-assembled magnetic anastomosis ring (DSAMAR) for colonic anastomosis for use in single-approach operation and evaluate its feasibility and safety through animal experiments.
The animal model for colonic stenosis was prepared by partial colonic ligation in eight beagles. The magnetic compression anastomosis of their colonic stricture was performed by endoscopically assisted transanal implantation of the DSAMAR. The anastomotic specimen, obtained 2 wk after the operation, was observed by both the naked eye and a light microscope.
The DSAMAR was successfully inserted into the proximal end of colon stenosis through the anus. The DSAMAR of seven dogs was successfully transformed into rings, while that of the remaining dog was removed after the first deformation failed. The rings were successfully retransformed after optimization. All animals underwent colonic anastomosis using the DSAMAR. No device-related or procedure-related adverse events were observed. The colostomy specimens of the experimental dogs were obtained 2 wk after the operation. Both gross and histological observations showed good anastomotic healing.
The DSAMAR is a safe and feasible option for the treatment of colon stenosis. Its specific deformation and self-assembly capability maximize the applicability of the minimally invasive treatment.
Core Tip: By combining magnetic compression anastomosis with endoscopic technology, we could design a deformable self-assembled magnetic anastomosis ring (DSAMAR) to perform magnetic compression anastomosis with only a single channel. We then verified the feasibility of magnetic compression anastomosis for the recanalization of colonic stenosis through animal experiments. The results showed that minimally invasive treatment of colonic stenosis can be achieved using the DSAMAR.