Published online Sep 7, 2023. doi: 10.3748/wjg.v29.i33.4962
Peer-review started: June 27, 2023
First decision: July 25, 2023
Revised: August 7, 2023
Accepted: August 17, 2023
Article in press: August 17, 2023
Published online: September 7, 2023
Processing time: 65 Days and 17 Hours
Splanchnic vein thrombosis (SVT) is a manifestation of venous thromboembolism in an unusual site. Portal, mesenteric, and splenic veins are the most common vessels involved in SVT which occurs mainly in patients with liver cirrhosis, although non-cirrhotic patients could be affected as well. Thrombosis of hepatic veins, also known as Budd-Chiari syndrome, is another manifestation of SVT. Prompt diagnosis and intervention are mandatory in order to increase the recalization rate and reduce the risk of thrombus progression and hypertensive complications. Traditional anticoagulation with heparin and vitamin-K antagonists is the treatment of choice in these cases. However, recent studies have shown promising results on the efficacy and safety of direct oral anticoagulants (DOACs) in this setting. Available results are mainly based on retrospective studies with small sample size, but first clinical trials have been published in the last years. This manuscript aims to provide an updated overview of the current evidence regarding the role of DOACs for SVT in both cirrhotic and non-cirrhotic patients.
Core Tip: The term splanchnic vein thrombosis (SVT) includes portal vein thrombosis and Budd-Chiari syndrome. Both conditions could occur in patients with and without an underlying liver disease. The cornerstone of treatment is anticoagulation. Direct oral anticoagulants (DOACs) are a novel class of drugs that have strongly affirmed their role in the management of patients with atrial fibrillation and venous thromboembolism. In the last few years, several studies have been published showing promising results in efficacy and safety of DOACs in patients with SVT.