Chaudhry H, Sohal A, Iqbal H, Roytman M. Alcohol-related hepatitis: A review article. World J Gastroenterol 2023; 29(17): 2551-2570 [PMID: 37213401 DOI: 10.3748/wjg.v29.i17.2551]
Corresponding Author of This Article
Hunza Chaudhry, MD, Staff Physician, Department of Internal Medicine, University of California, San Francisco, 155 N. Fresno St, Fresno, CA 93701, United States. hunza.chaudhry@ucsf.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hunza Chaudhry, Humzah Iqbal, Department of Internal Medicine, University of California, San Francisco, Fresno, CA 93701, United States
Aalam Sohal, Department of Hepatology, Liver Institute Northwest, Seattle, WA 98105, United States
Marina Roytman, Department of Gastroenterology and Hepatology, University of California, San Francisco, Fresno, CA 93701, United States
Author contributions: Chaudhry H, Sohal A and Iqbal H reviewed the literature, drafted the manuscript, revised it for important intellectual content and were involved in the final approval of the version to be published; Roytman M revised the article for important intellectual content and was involved in the final approval of the version to be published; All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hunza Chaudhry, MD, Staff Physician, Department of Internal Medicine, University of California, San Francisco, 155 N. Fresno St, Fresno, CA 93701, United States. hunza.chaudhry@ucsf.edu
Received: December 26, 2022 Peer-review started: December 26, 2022 First decision: March 8, 2023 Revised: March 10, 2023 Accepted: April 13, 2023 Article in press: April 13, 2023 Published online: May 7, 2023 Processing time: 132 Days and 0.9 Hours
Abstract
Alcohol-related hepatitis (ARH) is a unique type of alcohol-associated liver disease characterized by acute liver inflammation caused by significant alcohol use. It ranges in severity from mild to severe and carries significant morbidity and mortality. The refinement of scoring systems has enhanced prognostication and guidance of clinical decision-making in the treatment of this complex disease. Although treatment focuses on supportive care, steroids have shown benefit in select circumstances. There has been a recent interest in this disease process, as coronavirus disease 2019 pandemic led to substantial rise in cases. Although much is known regarding the pathogenesis, prognosis remains grim due to limited treatment options. This article summarizes the epidemiology, genetics, pathogenesis, diagnosis and treatment of ARH.
Core Tip: The aim of this article is to review alcohol-related hepatitis (ARH). Despite the increased understanding of the pathogenesis of this disease process, treatment options remain limited. Our review article focuses on epidemiology, genetics, pathogenesis, diagnosis and treatment. We also discuss complications of ARH along with their optimal management and ongoing clinical trials. Further research evaluating therapeutic targets for its management are warranted.
