Mc Gettigan N, O'Toole A, Boland K. “Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel disease”: A letter to the editor. World J Gastroenterol 2022; 28(8): 878-880 [PMID: 35317102 DOI: 10.3748/wjg.v28.i8.878]
Corresponding Author of This Article
Neasa Mc Gettigan, MBChB, MRCP, MSc, Research Fellow, Department of Gastroenterology, Beaumont Hospital, Beaumont Road, Dublin D09V2N0, Leinster, Ireland. neasa13@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Feb 28, 2022; 28(8): 878-880 Published online Feb 28, 2022. doi: 10.3748/wjg.v28.i8.878
“Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel disease”: A letter to the editor
Neasa Mc Gettigan, Aoibhlinn O'Toole, Karen Boland
Neasa Mc Gettigan, Aoibhlinn O'Toole, Karen Boland, Department of Gastroenterology, Beaumont Hospital, Dublin D09V2N0, Leinster, Ireland
Neasa Mc Gettigan, Aoibhlinn O'Toole, Karen Boland, School of Medicine, Royal College of Surgeons, Dublin D02YN77, Ireland
Author contributions: Mc Gettigan N wrote the letter, O’Toole A and Boland K revised the letter.
Conflict-of-interest statement: The authors have no conflict-of-interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Neasa Mc Gettigan, MBChB, MRCP, MSc, Research Fellow, Department of Gastroenterology, Beaumont Hospital, Beaumont Road, Dublin D09V2N0, Leinster, Ireland. neasa13@gmail.com
Received: September 13, 2021 Peer-review started: September 13, 2021 First decision: November 7, 2021 Revised: November 10, 2021 Accepted: January 19, 2022 Article in press: January 19, 2022 Published online: February 28, 2022 Processing time: 163 Days and 15.8 Hours
Abstract
Exercise-induced changes of the microbiome in inflammatory bowel diseases (IBD) is a promising field of research with the potential for personalized exercise regimes as a promising therapeutic adjunct for restoring gut dysbiosis and additionally for regulating immunometabolic pathways in the management of IBD patients. Structured exercise programmes in IBD patients of at least of 12 wk duration are more likely to result in disease-altering changes in the gut microbiome and to harness potential anti-inflammatory effects through these changes along with immunometabolic pathways.
Core Tip: Exercise-induced changes of the microbiome in inflammatory bowel diseases (IBD) is a promising field of research with the potential for personalized exercise regimes as a promising therapeutic adjunct for restoring gut dysbiosis and additionally for regulating immunometabolic pathways in the management of IBD patients. We have observed that exercise programmes of at least 12 wk duration are required to exert any meaningful effects on gut dysbiosis restoration and suggest that the positive effects of a more prolonged programme may extend to inflammatory mediation through regulation of immunometabolism.
