Ikeda Y, Taniguchi K, Sawamura H, Tsuji A, Matsuda S. Promising role of D-amino acids in irritable bowel syndrome. World J Gastroenterol 2022; 28(31): 4471-4474 [PMID: 36159020 DOI: 10.3748/wjg.v28.i31.4471]
Corresponding Author of This Article
Satoru Matsuda, MD, PhD, Professor, Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan. smatsuda@cc.nara-wu.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 21, 2022; 28(31): 4471-4474 Published online Aug 21, 2022. doi: 10.3748/wjg.v28.i31.4471
Promising role of D-amino acids in irritable bowel syndrome
Yuka Ikeda, Kurumi Taniguchi, Haruka Sawamura, Ai Tsuji, Satoru Matsuda
Yuka Ikeda, Kurumi Taniguchi, Haruka Sawamura, Ai Tsuji, Satoru Matsuda, Department of Food Science and Nutrition, Nara Women's University, Nara 630-8506, Japan
Author contributions: Ikeda Y and Matsuda S contributed equally to this work; Ikeda Y, Taniguchi K, Sawamura H, Tsuji A, and Matsuda S designed the research study and wrote the manuscript; and all authors have read and approved the final manuscript.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Satoru Matsuda, MD, PhD, Professor, Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan. smatsuda@cc.nara-wu.ac.jp
Received: April 4, 2022 Peer-review started: April 4, 2022 First decision: May 29, 2022 Revised: June 14, 2022 Accepted: July 20, 2022 Article in press: July 20, 2022 Published online: August 21, 2022
Abstract
Irritable bowel syndrome (IBS) is an important health care concern. Alterations in the microbiota of the gut-brain axis may be linked to the pathophysiology of IBS. Some dietary intake could contribute to produce various metabolites including D-amino acids by the fermentation by the gut microbiota. D-amino acids are the enantiomeric counterparts of L-amino acids, in general, which could play key roles in cellular physiological processes against various oxidative stresses. Therefore, the presence of D-amino acids has been shown to be linked to the protection of several organs in the body. In particular, the gut microbiota could play significant roles in the stability of emotion via the action of D-amino acids. Here, we would like to shed light on the roles of D-amino acids, which could be used for the treatment of IBS.
