Weng CY, Xu JL, Sun SP, Wang KJ, Lv B. Helicobacter pylori eradication: Exploring its impacts on the gastric mucosa. World J Gastroenterol 2021; 27(31): 5152-5170 [PMID: 34497441 DOI: 10.3748/wjg.v27.i31.5152]
Corresponding Author of This Article
Bin Lv, MM, Chief Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. lvbin@medmail.com.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 21, 2021; 27(31): 5152-5170 Published online Aug 21, 2021. doi: 10.3748/wjg.v27.i31.5152
Helicobacter pylori eradication: Exploring its impacts on the gastric mucosa
Chun-Yan Weng, Jing-Li Xu, Shao-Peng Sun, Kai-Jie Wang, Bin Lv
Chun-Yan Weng, Shao-Peng Sun, Kai-Jie Wang, Bin Lv, Department of Gastroenterology, The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Jing-Li Xu, Department of Gastrointestinal Surgery, The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Bin Lv, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Author contributions: All authors contributed to the collection of articles, data analysis, and the writing and editing of the final manuscript.
Supported byNational Natural Science Foundation of China, No. 722211A00352.
Conflict-of-interest statement: The authors have no potential conflict of interest related to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Lv, MM, Chief Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. lvbin@medmail.com.cn
Received: April 14, 2021 Peer-review started: April 14, 2021 First decision: June 3, 2021 Revised: June 14, 2021 Accepted: July 15, 2021 Article in press: July 15, 2021 Published online: August 21, 2021 Processing time: 126 Days and 5.8 Hours
Abstract
Helicobacter pylori (H. pylori) infects approximately 50% of all humans globally. Persistent H. pylori infection causes multiple gastric and extragastric diseases, indicating the importance of early diagnosis and timely treatment. H. pylori eradication produces dramatic changes in the gastric mucosa, resulting in restored function. Consequently, to better understand the importance of H. pylori eradication and clarify the subsequent recovery of gastric mucosal functions after eradication, we summarize histological, endoscopic, and gastric microbiota changes to assess the therapeutic effects on the gastric mucosa.
Core Tip: Eradication of Helicobacter pylori (H. pylori) is important. Multiple gastrointestinal diseases and extragastric diseases would emerge if H. pylori infection persists, whereas they would improve after H. pylori eradication. Thus, H. pylori eradication produces dramatic changes in the gastric mucosa. This review highlights the most recent literature and presents a comprehensive evaluation about the impact of H. pylori eradication on the gastric mucosa.
