Published online Jun 14, 2021. doi: 10.3748/wjg.v27.i22.2944
Peer-review started: January 29, 2021
First decision: February 24, 2021
Revised: March 6, 2021
Accepted: April 25, 2021
Article in press: April 25, 2021
Published online: June 14, 2021
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health worldwide. In addition to respiratory symptoms, COVID-19 is usually accompanied by systemic inflammation and liver damage in moderate and severe cases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the expression of antioxidant proteins, participating in COVID-19-mediated inflammation and liver injury. Here, we show the novel reciprocal regulation between NRF2 and inflammatory mediators associated with COVID-19-related liver injury. Additionally, we describe some mechanisms and treatment strategies.
Core Tip: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health worldwide. In this review, we provide the most comprehensive guide to nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury, emphasizing their potential as targets for COVID-19 therapy.