Chen JH, Lin L, Liu KL, Su H, Wang LL, Ding PP, Zhou Q, Liu H, Wu J. Malignant glomus tumor of the intestinal ileum with multiorgan metastases: A case report and review of literature. World J Gastroenterol 2020; 26(7): 770-776 [PMID: 32116424 DOI: 10.3748/wjg.v26.i7.770]
Corresponding Author of This Article
Jing Wu, MD, PhD, Professor, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University; National Clinical Research Center for Digestive Diseases; Beijing Digestive Disease Center; Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, No. 95 Yongan Road, Xicheng District, Beijing 100050, China. wujing36@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Feb 21, 2020; 26(7): 770-776 Published online Feb 21, 2020. doi: 10.3748/wjg.v26.i7.770
Malignant glomus tumor of the intestinal ileum with multiorgan metastases: A case report and review of literature
Jian-Hong Chen, Lin Lin, Kui-Liang Liu, Hui Su, Ling-Ling Wang, Peng-Peng Ding, Quan Zhou, Hong Liu, Jing Wu
Jian-Hong Chen, Lin Lin, Kui-Liang Liu, Hui Su, Peng-Peng Ding, Hong Liu, Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Ling-Ling Wang, Quan Zhou, Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Jing Wu, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University; National Clinical Research Center for Digestive Diseases; Beijing Digestive Disease Center; Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing 100050, China
Author contributions: Chen JH, Lin L, Liu KL, and Wu J designed this report; Su H performed the capsule endoscopy examination for the patient; Wang LL and Zhou Q performed the histopathological and immunohistochemical analyses; Chen JH, Lin L, Liu KL, and Ding PP followed the patient and recorded his medical information; Chen JH wrote the paper.
Supported bythe National Natural Science Foundation of China, No. 81900505.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jing Wu, MD, PhD, Professor, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University; National Clinical Research Center for Digestive Diseases; Beijing Digestive Disease Center; Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, No. 95 Yongan Road, Xicheng District, Beijing 100050, China. wujing36@163.com
Received: November 25, 2019 Peer-review started: November 25, 2019 First decision: December 12, 2019 Revised: January 8, 2020 Accepted: January 15, 2020 Article in press: January 15, 2020 Published online: February 21, 2020 Processing time: 87 Days and 10.9 Hours
Abstract
BACKGROUND
Glomus tumors (GTs) are rare mesenchymal neoplastic lesions derived from cells of the glomus body. GTs rarely occurs in the visceral organs, where there may be few or no glomus bodies, and the majority of GTs are benign, rarely demonstrating aggressive or malignant behavior and histological features.
CASE SUMMARY
We report a patient with malignant GTs of the intestinal ileum with multiorgan metastases who was admitted due to moderate anemia. Capsule endoscopy revealed a bleeding mass in the intestinal ileum, and the patient underwent segmental ileal resection through laparoscopic surgery. The histopathological and immunohistochemical diagnoses were consistent with malignant GT. Long-term follow-up showed that the GT had metastasized to multiple organs such as the colon, brain, and possibly the lung.
CONCLUSION
This case was characterized by the highest degree of malignancy and by multiorgan metastases, and it was the first case of intestinal GT uncovered by capsule endoscopy.
Core tip: We report a patient with malignant glomus tumors of the intestinal ileum characterized by the highest degree of malignancy and multiorgan metastases, and it was the first case of intestinal glomus tumor uncovered by capsule endoscopy. We further reviewed the literature on the clinicopathologic features, diagnosis, and treatment of intestinal glomus tumors.
