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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Clinical impact of surveillance for head and neck cancer in patients with esophageal squamous cell carcinoma
Hiroyuki Morimoto, Tomonori Yano, Yusuke Yoda, Yasuhiro Oono, Hiroaki Ikematsu, Ryuichi Hayashi, Atsushi Ohtsu, Kazuhiro Kaneko
Hiroyuki Morimoto, Tomonori Yano, Yusuke Yoda, Yasuhiro Oono, Hiroaki Ikematsu, Kazuhiro Kaneko, Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan
Hiroyuki Morimoto, Atsushi Ohtsu, Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Kashiwa, Chiba 277-8577, Japan
Ryuichi Hayashi, Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan
Atsushi Ohtsu, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan
Kazuhiro Kaneko, Division of Science and Technology for Endoscopy, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan
Author contributions: Morimoto H and Yano T contributed equally to this work; Morimoto H and Yano T designed the research; Morimoto H, Yano T, Yoda Y, Oono Y, Ikematsu H and Kaneko K acquired data and performed the research; Morimoto H, Yano T and Kaneko K wrote the draft; Hayashi R and Ohtsu A supervised the report.
Institutional review board statement: This study was reviewed and approved by National Cancer Center Institutional Review Board (2012-331).
Informed consent statement: All study participated patients provided written informed consent before enrollment and any intervention and examination in this study. For full disclosure, the details of the study are published on the home page of National Cancer Center.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tomonori Yano, MD, Chief, Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwanoha 6-5-1, Kashiwa, Chiba 277-8577, Japan. toyano@east.ncc.go.jp
Telephone: +81-4-71331111 Fax: +81-4-71314724
Received: September 13, 2016
Peer-review started: September 16, 2016
First decision: October 28, 2016
Revised: November 24, 2016
Accepted: January 18, 2017
Article in press: January 18, 2017
Published online: February 14, 2017
AIM
To evaluate the clinical impact of surveillance for head and neck (HN) region with narrow band imaging (NBI) in patients with esophageal squamous cell carcinoma (ESCC).
METHODS
Since 2006, we introduced the surveillance for HN region using NBI for all patients with ESCC before treatment, and each follow-up. The patients with newly diagnosed stage I to III ESCC were enrolled and classified into two groups as follows: Group A (no surveillance for HN region); between 1992 and 2000), and Group B (surveillance for HN region with NBI; between 2006 and 2008). We comparatively evaluated the detection rate of superficial head and neck squamous cell carcinoma (HNSCC), and the serious events due to metachronous advanced HNSCC during the follow-up.
RESULTS
A total 561 patients (group A: 254, group B: 307) were enrolled. Synchronous superficial HNSCC was detected in 1 patient (0.3%) in group A, and in 12 (3.9%) in group B (P = 0.008). During the follow up period, metachronous HNSCC were detected in 10 patients (3.9%) in group A and in 30 patients (9.8%) in group B (P = 0.008). All metachronous lesions in group B were early stage, and 26 patients underwent local resection, however, 6 of 10 patients (60%) in group A lost their laryngeal function and died with metachronous HNSCC.
CONCLUSION
Surveillance for the HN region by using NBI endoscopy increase the detection rate of early HNSCC in patients with ESCC, and led to decrease serious events related to advanced metachronous HNSCC.
Core tip: This is a retrospective study to evaluate the clinical impact of intensive surveillance for head and neck (HN) region by using narrow band imaging (NBI) endoscopy in patients with esophageal squamous cell carcinoma. The detection rate of superficial head and neck squamous cell carcinoma (HNSCC) which could be easily treated with endoscopic resection was dramatically increased after introduction of surveillance for HN region with NBI, and the serious events (loss of laryngeal function, death) due to metachronous advanced HNSCC were led to decrease when comparing with historical control. Surveillance for HN region with NBI might have a clinical impact at the point of reduction of head and neck cancer death in esophageal cancer survivor.
