Published online Jan 28, 2017. doi: 10.3748/wjg.v23.i4.638
Peer-review started: September 6, 2016
First decision: October 11, 2016
Revised: December 5, 2016
Accepted: December 21, 2016
Article in press: December 21, 2016
Published online: January 28, 2017
Processing time: 136 Days and 21.5 Hours
To identify the predictors of vitamin D deficiency in patients with and without inflammatory bowel disease (IBD).
Patients with ulcerative colitis (UC) or Crohn’s disease (CD) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were identified. After thorough chart review, we identified patients with biopsy proven IBD who had also been tested for serum 25-hydroxyvitamin D [25(OH)D] concentration. We compared these patients to a previously studied cohort of healthy controls who also had vitamin D concentration checked. Logistic regression analysis was performed to determine the association between vitamin d deficiency and UC, CD, race, age, gender and body mass index (BMI).
We identified 237 patients with confirmed IBD. Of these, only 211 had a serum 25(OH)D concentrations available in the medical record. The group of healthy controls consisted of 98 individuals with available serum 25(OH)D concentration. 43% of IBD patients were African American (AA). Patients with CD were more likely to have vitamin D concentration checked. Bivariate analysis showed that AA (51% vs 21%, P = 0.00001), subjects with BMI >30 kg/m2 (39% vs 23% P = 0.01) and CD (40% vs 26%, P = 0.04) were more likely to be vitamin D deficient than vitamin D sufficient. Those with Age > 65 were more likely to be vitamin D sufficient (46% vs 15%, P = 0.04). Multiple regression showed that only BMI > 30 kg/m2 and AA race are associated with vitamin D deficiency.
BMI > 30 kg/m2 and AA race are predictive of vitamin D deficiency. Gender, age and diagnosis of IBD are not predictive of vitamin D deficiency.
Core tip: The studies evaluating the relationship between vitamin D deficiency and inflammatory bowel disease (IBD) have shown heterogeneity perhaps due to multiple overlapping risk factors that need to be accounted for. We performed a retrospective study to identify the risk factors for vitamin D deficiency in a population with a large African American (AA) component. Using logistic regression analysis we studied the effect of diagnosis, race, age, gender and body mass index (BMI) on prevalence of vitamin D deficiency. In subjects with and without IBD, BMI > 30 kg/m2 and AA race are predictive of vitamin D deficiency. Gender, age and diagnosis of IBD were not predictive of vitamin D deficiency in our population.