Manabe S, Mukaisho KI, Yasuoka T, Usui F, Matsuyama T, Hirata I, Boku Y, Takahashi S. Gastric adenocarcinoma of fundic gland type spreading to heterotopic gastric glands. World J Gastroenterol 2017; 23(38): 7047-7053 [PMID: PMC5658322 DOI: 10.3748/wjg.v23.i38.7047]
Corresponding Author of This Article
Shigeo Manabe, MD, Department of Gastroenterology, Kouseikai Takeda Hospital, 841-5, Higashi Shiokoji-cho, Shiokoji-dori Nishinotoin-higashiiru, Shimogyo-ku, Kyoto 600-8558, Japan. s-manabe@takedahp.or.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Author contributions: Manabe S was responsible for the patient, performed the endoscopic examination and treatment, and wrote the initial draft of the manuscript; Mukaisho K contributed to the histopathological diagnosis; all other authors contributed to the retrieval and interpretation of the results and critically reviewed the manuscript; all authors approved the final version of the manuscript.
Institutional review board statement: This case report was exempted from the standards of the Institutional Review Board at the Kouseikai Takeda Hospital.
Informed consent statement: The patient provided an oral informed consent prior to the conduction of the study.
Conflict-of-interest statement: We declare that there is no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shigeo Manabe, MD, Department of Gastroenterology, Kouseikai Takeda Hospital, 841-5, Higashi Shiokoji-cho, Shiokoji-dori Nishinotoin-higashiiru, Shimogyo-ku, Kyoto 600-8558, Japan. s-manabe@takedahp.or.jp
Telephone: +81-75-3611351 Fax: +81-75-3617602
Received: June 6, 2017 Peer-review started: June 14, 2017 First decision: July 17, 2017 Revised: August 18, 2017 Accepted: September 13, 2017 Article in press: September 13, 2017 Published online: October 14, 2017 Processing time: 124 Days and 19.5 Hours
Abstract
Herein, we present a case of gastric adenocarcinoma of fundic gland type (GA-FG) spreading to heterotopic gastric glands (HGG) in the submucosa. A 58-year-old man with epigastric pain was referred to our hospital and underwent an esophagogastroduodenoscopy. A Borrmann type II gastric cancer at the antrum and a 10 mm submucosal tumor-like lesion in the lesser curvature of the upper third of the stomach were detected. Histological examination of the biopsy specimens obtained from the submucosal tumor-like lesion suggested a GA-FG. Therefore, endoscopic submucosal dissection was performed as excisional biopsy, and histopathological examination of the resected specimen confirmed a GA-FG and HGG proximal to the GA-FG. Although the GA-FG invaded the submucosal layer slightly, the submucosal lesion of the GA-FG had a poor stromal reaction and was located just above the HGG in the submucosa. Therefore, we finally diagnosed the lesion as a GA-FG invading the submucosal layer by spreading to HGG.
Core tip: A 58-year-old man had a 10mm submucosal tumor-like lesion in the lesser curvature of the upper third of the stomach. Histological examination of the biopsy specimens suggested a gastric adenocarcinoma of fundic gland type (GA-FG), therefore, endoscopic submucosal dissection was performed as excisional biopsy. Histopathological examination of the resected specimen confirmed a GA-FG invading the submucosal layer slightly, and heterotopic gastric glands (HGG) proximal to the GA-FG. A GA-FG spreading to HGG in the submucosa was diagnosed because the submucosal lesion of the GA-FG had a poor stromal reaction and was located just above the HGG.
