Published online Jul 21, 2017. doi: 10.3748/wjg.v23.i27.4968
Peer-review started: December 29, 2016
First decision: March 16, 2017
Revised: April 17, 2017
Accepted: June 9, 2017
Article in press: June 12, 2017
Published online: July 21, 2017
To obtain a reference range of morphological indices and establish a formula to accurately predict standard liver volume (SLV) in Chinese adults.
Computed tomography (CT)-estimated total liver volume (CTLV) was determined in 369 Chinese adults. Age, sex, body weight, body height, body mass index, and body surface area (BSA) were recorded using CT. Total splenic volume, portal venous diameter (PVD), splenic venous diameter (SVD), and portal venous cross-sectional area (PVCSA) were also measured by CT. Stepwise multiple linear regression analysis was performed to evaluate the impact of each parameter on CTLV and to develop a new SLV formula. The accuracy of the new formula was compared with the existing formulas in a validation group.
The average CTLV was 1205.41 ± 257.53 cm3 (range, 593.80-2250.10 cm3). The average of PVD, SVD and PVCSA was 9.34 ± 1.51 mm, 7.40 ± 1.31 mm and 173.22 ± 48.11 mm2, respectively. The CT-estimated splenic volume of healthy adults varied markedly (range, 46.60-2892.30 cm3). Sex, age, body height, body weight, body mass index, and BSA were significantly correlated with CTLV. BSA showed the strongest correlation (r = 0.546, P < 0.001), and was used to establish a new model for calculating SLV: SLV (cm3) = 758.259 × BSA (m2)-124.272 (R2 = 0.299, P < 0.001). This formula also predicted CTLV more accurately than the existing formulas, but overestimated CTLV in elderly subjects > 70 years of age, and underestimated liver volume when CTLV was > 1800 cm3.
Our new BSA-based formula is more accurate than other formulas in estimating SLV in Chinese adults.
Core tip: This was a prospective international phase II trial with 16 patients seeking to evaluate the effect of selenomethionine on acute toxicity in the setting of concurrent chemoradiaiton for locally advanced, inoperable non-small cell lung cancer. Selenium proved to be well tolerated and led to significantly reduced rates of myelosuppression.