Choi KW, Joo M, Kim HS, Lee WY. Synchronous triple occurrence of MALT lymphoma, schwannoma, and adenocarcinoma of the stomach. World J Gastroenterol 2017; 23(22): 4127-4131 [PMID: 28652666 DOI: 10.3748/wjg.v23.i22.4127]
Corresponding Author of This Article
Woo Y Lee, MD, Department of Surgery, Seoul Paik Hospital, Inje University College of Medicine, 9 Mareunnae-ro, Jung-gu, Seoul 100-032, South Korea. yongaaa5972@naver.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 14, 2017; 23(22): 4127-4131 Published online Jun 14, 2017. doi: 10.3748/wjg.v23.i22.4127
Synchronous triple occurrence of MALT lymphoma, schwannoma, and adenocarcinoma of the stomach
Kyeong W Choi, Mee Joo, Han S Kim, Woo Y Lee
Kyeong W Choi, Woo Y Lee, Department of Surgery, Seoul Paik Hospital, Inje University College of Medicine, Seoul 100-032, South Korea
Mee Joo, Han S Kim, Department of Pathology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang-si Gyeonggi-do 411-706, South Korea
Author contributions: Choi KW and Lee WY designed the report; Joo M and Kim HS performed histologic analysis; Choi KW and Lee WY wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Seoul Paik Hospital Institutional Review Board, PAIK-2016-12-012.
Informed consent statement: The patient presented in this case report gave his written informed consent authorizing use and disclosure of his protected health information.
Conflict-of-interest statement: There is no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Woo Y Lee, MD, Department of Surgery, Seoul Paik Hospital, Inje University College of Medicine, 9 Mareunnae-ro, Jung-gu, Seoul 100-032, South Korea. yongaaa5972@naver.com
Telephone: +82-2-22700247 Fax: +82-2-22700250
Received: January 10, 2017 Peer-review started: January 12, 2017 First decision: March 3, 2017 Revised: March 14, 2017 Accepted: April 12, 2017 Article in press: April 12, 2017 Published online: June 14, 2017
Abstract
We present a case of a 56-year-old man with 3 synchronous gastric tumors. The patient presented with melena, and 3 gastric abnormalities were detected on gastroduodenoscopic examination, including a small ulcerative lesion in the gastric antrum, a submucosal mass in the gastric body, and severe erosion in the fundus. Histological examination of biopsy samples yielded respective diagnoses of gastric adenocarcinoma, gastritis, and mucosa-associated lymphoid tissue (MALT) lymphoma. The patient first received medication to eradicate any underlying Helicobacter pylori infection, which might have been a cause of the MALT lymphoma. Four weeks later, after examination of repeat biopsy samples revealed that the MALT lymphoma had resolved, the patient underwent subtotal gastrectomy. Further histological examination of resected tissue confirmed the antrum lesion as adenocarcinoma and the body lesion as schwannoma. To our knowledge, this is the first reported case of synchronous triple primary gastric adenocarcinoma, MALT lymphoma, and schwannoma.
Core tip: Synchronous occurrence of two types of gastric tumor is relatively well described, but this is the first report of synchronous triple gastric adenocarcinoma, mucosa-associated lymphoid tissue (MALT) lymphoma, and schwannoma. Consideration of the possible underlying involvement of Helicobacter pylori in MALT lymphoma and preoperative treatment with appropriate medication allowed performance of subtotal gastrectomy and a successful outcome.
