Observational Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2017; 23(15): 2795-2801
Published online Apr 21, 2017. doi: 10.3748/wjg.v23.i15.2795
Endoscopic ultrasound-guided cutting of holes and deep biopsy for diagnosis of gastric infiltrative tumors and gastrointestinal submucosal tumors using a novel vertical diathermic loop
Yu-Mei Liu, Xiu-Jiang Yang
Yu-Mei Liu, Xiu-Jiang Yang, Department of Endoscopy, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Yu-Mei Liu, Xiu-Jiang Yang, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Author contributions: Liu YM drafted the manuscript and assisted with data collection and analysis; Yang XJ participated in the design and oversight of the study and performed the majority of operations; all authors read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board and Ethics Committee of Fudan University Shanghai Cancer Center.
Informed consent statement: Informed consent was obtained from all participants or their legal guardian.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.
Data sharing statement: There is no additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiu-Jiang Yang, MD, Professor, Department of Endoscopy, Fudan University Shanghai Cancer Center, 270 Dong’an Road, Shanghai 200032, China. yangxj1960@163.com
Telephone: +86-21-34610367
Received: January 5, 2017
Peer-review started: January 5, 2017
First decision: February 9, 2017
Revised: February 13, 2017
Accepted: March 15, 2017
Article in press: March 15, 2017
Published online: April 21, 2017
Processing time: 105 Days and 5.3 Hours
Abstract
AIM

To report on a more accurate diagnostic possibility offered by endoscopic ultrasound-guided cutting of holes and deep biopsy (EUS-CHDB) for pathologic diagnosis of gastric infiltrative tumors and gastrointestinal submucosal tumors.

METHODS

Ten consecutive patients who were suspected of having gastric invasive tumors or gastrointestinal submucosal tumors underwent EUS-CHDB with a novel vertical diathermic loop. We reviewed their medical data and analysed the effectiveness and safety of this new method. The final diagnosis was based on the surgical pathology or clinical/imaging follow-up.

RESULTS

EUS-CHDB was performed successfully in all the ten patients. Neither severe haemorrhage nor perforation occurred in any patient. Among the ten patients, there were three cases of gastric linitis plastica, one case of gastric lymphoma, five cases of gastrointestinal stromal tumors (GISTs), and only one case of chronic non-atrophic gastritis. That is, nine (90%) of the cases treated by EUS-CHDB showed positive findings.

CONCLUSION

EUS-CHDB may be a technically feasible and safe option for patients with gastric infiltrative tumors or gastrointestinal submucosal tumors. EUS-CHDB may be used as a remedial or even preferred biopsy method for submucosal lesions.

Keywords: Endoscopic ultrasound; Cutting holes; Deep biopsy; Vertical diathermic loop; Gastric linitis plastica; Gastrointestinal submucosal tumors

Core tip: This was a prospective clinical diagnostic trial seeking to evaluate the efficacy of endoscopic ultrasound-guided cutting of holes and deep biopsy for the diagnosis of gastric infiltrative tumors and gastrointestinal submucosal tumors using a novel vertical diathermic loop. This new technique was proved to be a safe, technically feasible and more accurate option for patients with gastric infiltrative tumors or gastrointestinal submucosal tumors.