Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2017; 23(11): 2012-2022
Published online Mar 21, 2017. doi: 10.3748/wjg.v23.i11.2012
Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer
Yu-Qin Sun, Jian-Wei Xie, Hong-Teng Xie, Peng-Chen Chen, Xiu-Li Zhang, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Long-Long Cao, Chang-Ming Huang, Yao Lin
Yu-Qin Sun, Hong-Teng Xie, Peng-Chen Chen, Xiu-Li Zhang, Yao Lin, College of Life Sciences, Fujian Normal University, Fuzhou 350108, Fujian Province, China
Yu-Qin Sun, Jian-Wei Xie, Hong-Teng Xie, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Long-Long Cao, Chang-Ming Huang, Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China
Author contributions: Sun YQ and Xie JW contributed equally to this article; Huang CM and Lin Y conceived and designed the study; Sun YQ, Xie JW, Xie HT, Chen PC and Zhang XL performed the experiments; Zheng CH, Li P, Wang JB, Lin JX and Cao LL analyzed and interpreted the data; Sun YQ and Xie JW drafted the manuscript.
Supported by National Natural Science Foundation of China, No. 81441123 (to Huang CM), No. 31640053 (to Lin Y); National Key Clinical Specialty Discipline Construction Program of China, No. [2012]649; Key Scientific and Technological Project of Fujian Province, China, No. 2014Y0025 (to Huang CM); and Natural Science Foundation of Fujian Province, China, No. 2014J01322 (to Xie JW), No. 2016Y0029 (to Lin Y).
Conflict-of-interest statement: The authors declare that no conflict of interest exists.
Data sharing statement: All available data can be obtained by contacting the corresponding author.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Yao Lin, Professor, College of Life Sciences, Fujian Normal University, Qishan Campus, Fuzhou 350108, Fujian Province, China. yaolin@fjnu.edu.cn
Telephone: +86-591-22868688
Received: November 3, 2016
Peer-review started: November 4, 2016
First decision: December 28, 2016
Revised: December 30, 2016
Accepted: January 4, 2017
Article in press: January 4, 2017
Published online: March 21, 2017
Processing time: 136 Days and 6.3 Hours
Abstract
AIM

To evaluate the predictive value of the expression of chromosomal maintenance (CRM)1 and cyclin-dependent kinase (CDK)5 in gastric cancer (GC) patients after gastrectomy.

METHODS

A total of 240 GC patients who received standard gastrectomy were enrolled in the study. The expression level of CRM1 and CDK5 was detected by immunohistochemistry. The correlations between CRM1 and CDK5 expression and clinicopathological factors were explored. Univariate and multivariate survival analyses were used to identify prognostic factors for GC. Receiver operating characteristic analysis was used to compare the accuracy of the prediction of clinical outcome by the parameters.

RESULTS

The expression of CRM1 was significantly related to size of primary tumor (P = 0.005), Borrmann type (P = 0.006), degree of differentiation (P = 0.004), depth of invasion (P = 0.008), lymph node metastasis (P = 0.013), TNM stage (P = 0.002) and distant metastasis (P = 0.015). The expression of CDK5 was significantly related to sex (P = 0.048) and Lauren’s classification (P = 0.011). Multivariate Cox regression analysis identified that CRM1 and CDK5 co-expression status was an independent prognostic factor for overall survival (OS) of patients with GC. Integration of CRM1 and CDK5 expression could provide additional prognostic value for OS compared with CRM1 or CDK5 expression alone (P = 0.001).

CONCLUSION

CRM1 and CDK5 co-expression was an independent prognostic factors for GC. Combined CRM1 and CDK5 expression could provide a prognostic model for OS of GC.

Keywords: Gastric cancer; CRM1; CDK5; Prognosis

Core tip: Our study shows that low expression of chromosomal maintenance (CRM)1 and cyclin-dependent kinase (CDK)5 was associated with poor prognosis of gastric cancer patients. The expression of CRM1 or CDK5 influenced the prognostic value of each other. Combined CRM1 and CDK5 expression had better prognostic power than their individual expression had.