Published online Dec 7, 2016. doi: 10.3748/wjg.v22.i45.9994
Peer-review started: July 12, 2016
First decision: July 29, 2016
Revised: October 2, 2016
Accepted: November 12, 2016
Article in press: November 13, 2016
Published online: December 7, 2016
Processing time: 151 Days and 13.4 Hours
To evaluate the clinical significance of the preoperative fibrinogen plasma level as a prognostic marker after surgery for colorectal cancer.
This retrospective study analysed 652 patients undergoing surgery for stage I-IV colorectal cancer between January 2005 and December 2012, at the Division of General Surgery A, University of Verona Hospital Trust, in whom preoperative fibrinogen plasma values were assessed at baseline. Fibrinogen is involved in tumourigenesis as well as tumour progression in several malignancies. Correlations between preoperative plasma fibrinogen values and clinicopathological characteristics were investigated. Univariate and multivariate survival analyses were performed to identify factors associated with overall and tumour-related survival.
Among the 652 patients, the fibrinogen value was higher than the threshold of 400 mg/dL in 345 patients (53%). The preoperative mean ± SD of fibrinogen was 426.2 ± 23.2 mg/dL (median: 409 mg/dL; range: 143-1045 mg/dL). Preoperative fibrinogen values correlated with age (P = 0.003), completeness of tumour resection, potentially curative vs palliative (P < 0.001), presence of systemic metastasis (P < 0.001), depth of tumour invasion pT (P < 0.001), nodes involvement pN (P = 0.001) and CEA serum level (P < 0.001). The mean fibrinogen value (± SD) was 395.6 ± 120.4 mg/dL in G1 tumours, 424.1 ± 121.4 mg/dL in G2 tumours and 453.4 ± 131.6 mg/dL in G3 tumours (P = 0.045). The overall survival and tumour-related survival were significantly higher in patients with fibrinogen values ≤ 400 mg/dL (P < 0.001). However, hyperfibrinogenemia did not retain statistical significance regarding either overall (P = 0.313) or tumour-related survival (P = 0.355) after controlling for other risk factors in a multivariate analysis.
Preoperative fibrinogen levels correlate with cancer severity but do not help in predicting patient prognosis after colorectal cancer surgery.
Core tip: Fibrinogen is involved in tumourigenesis and in tumour progression in several malignancies. Many studies, particularly from East, have shown a correlation between hyperfibrinogenemia and poor prognosis in patients with colorectal cancer (CRC). This study involves a large cohort of 652 Western patients underwent surgery for CRC. The analysis of our data demonstrates that preoperative fibrinogen plasma levels correlate with leading prognostic factors in patients undergoing surgery for CRC. Although long-term survival and tumour-related survival are worse in patients with hyperfibrinogenemia, these findings are not confirmed in multivariate analysis or after stratification of patients according to completeness of tumour resection and TNM stage.