Case Report
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2016; 22(44): 9865-9870
Published online Nov 28, 2016. doi: 10.3748/wjg.v22.i44.9865
Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother’s graft with von Meyenburg complex: A case report
Naoya Yamada, Yukihiro Sanada, Takumi Katano, Masahisa Tashiro, Yuta Hirata, Noriki Okada, Yoshiyuki Ihara, Atsushi Miki, Hideki Sasanuma, Taizen Urahashi, Yasunaru Sakuma, Koichi Mizuta
Naoya Yamada, Yukihiro Sanada, Takumi Katano, Masahisa Tashiro, Yuta Hirata, Noriki Okada, Yoshiyuki Ihara, Taizen Urahashi, Koichi Mizuta, Department of Transplant Surgery, Jichi Medical University, Shimotsuke-shi, Tochigi 329-0498, Japan
Atsushi Miki, Hideki Sasanuma, Yasunaru Sakuma, Department of Surgery, Jichi Medical University, Shimotsuke-shi, Tochigi 329-0498, Japan
Author contributions: Yamada N drafted the manuscript; Sanada Y, Katano T, Tashiro M, Hirata Y, Okada N, Ihara Y, Miki A, Sasanuma H, Urahashi T, Sakuma Y, and Mizuta K researched the literature, coordinated the management of the case, discussed the scientific issues regarding the management and helped to draft the manuscript; all authors read and approved the final manuscript.
Conflict-of-interest statement: The authors have no competing to disclose.
Institutional review board statement: This study was reviewed and approved by the Ethics Committees of Jichi Medical University, Tochigi, Japan (15-106).
Informed consent statement: The patient involved in this study gave her informed consent authorizing use and disclosure of her protected health information.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Naoya Yamada, MD, Department of Transplant Surgery, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi 329-0498, Japan. yn708@jichi.ac.jp
Telephone: +81-285-587069 Fax: +81-285-587069
Received: May 28, 2016
Peer-review started: May 30, 2016
First decision: July 29, 2016
Revised: August 30, 2016
Accepted: September 28, 2016
Article in press: September 28, 2016
Published online: November 28, 2016
Processing time: 182 Days and 2.7 Hours
Abstract

This is the first report of living donor liver transplantation (LDLT) for congenital hepatic fibrosis (CHF) using a mother’s graft with von Meyenburg complex. A 6-year-old girl with CHF, who suffered from recurrent gastrointestinal bleeding, was referred to our hospital for liver transplantation. Her 38-year-old mother was investigated as a living donor and multiple biliary hamartoma were seen on her computed tomography and magnetic resonance imaging scan. The mother’s liver function tests were normal and she did not have any organ abnormality, including polycystic kidney disease. LDLT using the left lateral segment (LLS) graft from the donor was performed. The donor LLS graft weighed 250 g; the graft recipient weight ratio was 1.19%. The operation and post-operative course of the donor were uneventful and she was discharged on post-operative day (POD) 8. The graft liver function was good, and the recipient was discharged on POD 31. LDLT using a graft with von Meyenburg complex is safe and useful. Long-term follow-up is needed with respect to graft liver function and screening malignant tumors.

Keywords: Congenital hepatic fibrosis; Von Meyenburg complex; Living donor liver transplantation; Pediatric liver transplantation

Core tip: Multiple biliary hamartoma is a rare, benign lesion known as von Meyenburg complex. This is the first report of living donor liver transplantation (LDLT) using a liver graft with von Meyenburg complex. A 6-year-old girl with congenital hepatic fibrosis, who suffered from recurrent gastrointestinal bleeding, was transplanted her mother’s liver graft with von Meyenburg complex. Successful LDLT was performed, and the liver and renal function after LDLT were good also in recipient and donor. LDLT using a graft with von Meyenburg complex is safe and useful for a further expansion of living donor pool. Long-term follow-up is needed with respect to graft liver function and screening malignant tumors.