Ikeura T, Miyoshi H, Shimatani M, Uchida K, Takaoka M, Okazaki K. Long-term outcomes of autoimmune pancreatitis. World J Gastroenterol 2016; 22(34): 7760-7766 [PMID: 27678359 DOI: 10.3748/wjg.v22.i34.7760]
Corresponding Author of This Article
Tsukasa Ikeura, MD, PhD, Department of Gastroenterology and Hepatology, Kansai Medical University, 2-3-1, Shinmachi, Hirakata, Osaka 573-1010, Japan. ikeurat@hirakata.kmu.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Tsukasa Ikeura, Hideaki Miyoshi, Masaaki Shimatani, Kazushige Uchida, Makoto Takaoka, Kazuichi Okazaki, Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Osaka 573-1010, Japan
Author contributions: Ikeura T, Miyoshi H and Shimatani M wrote the manuscript; Uchida K and Takaoka M made revision of the manuscript; Okazaki K made final approval of the manuscript to be published.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tsukasa Ikeura, MD, PhD, Department of Gastroenterology and Hepatology, Kansai Medical University, 2-3-1, Shinmachi, Hirakata, Osaka 573-1010, Japan. ikeurat@hirakata.kmu.ac.jp
Telephone: +81-72-8040101 Fax: +81-72-8042534
Received: March 28, 2016 Peer-review started: March 31, 2016 First decision: May 12, 2016 Revised: June 4, 2016 Accepted: June 28, 2016 Article in press: June 29, 2016 Published online: September 14, 2016 Processing time: 163 Days and 19.2 Hours
Abstract
Autoimmune pancreatitis (AIP) has been considered a favorable-prognosis disease; however, currently, there is limited information on natural course of AIP during long-term follow-up. Recently published studies regarding the long-term outcomes of AIP has demonstrated the developments of pancreatic stone formation, exocrine insufficiency, and endocrine insufficiency are observed in 5%-41%, 34%-82%, and 38%-57% of patients having the disease. Furthermore, the incidence rate of developing pancreatic cancer ranges from 0% to 4.8% during the long-term follow-up. The event of death from AIP-related complications other than accompanying cancer is likely to be rare. During follow-up of AIP patients, careful surveillance for not only relapse of the disease but also development of complications at regular intervals is needed.
Core tip: There is limited information on long-term outcomes of patients with autoimmune pancreatitis (AIP). This review provides a current overview of AIP regarding long-term outcomes such as pancreatic stone formation, pancreatic exocrine or endocrine dysfunction, associated malignancy, and mortality.
