Editorial
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2016; 22(16): 4073-4078
Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4073
Crohn's disease presenting as acute gastrointestinal hemorrhage
Amareshwar Podugu, Kanwarpreet Tandon, Fernando J Castro
Amareshwar Podugu, Kanwarpreet Tandon, Fernando J Castro, Department of Gastroenterology, Cleveland Clinic Florida, Weston, FL 33331, United States
Author contributions: Podugu A, Tandon T and Castro FJ searched the literature, formulated the tables, and wrote the manuscript; Castro FJ critically reviewed the manuscript.
Conflict-of-interest statement: There is no conflict to declare or no financial disclosures.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fernando J Castro, MD, Department of Gastroenterology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL 33331, United States. castrof@ccf.org
Telephone: +1-954-6595646 Fax: +1-954-6595647
Received: February 2, 2016
Peer-review started: February 9, 2016
First decision: March 7, 2016
Revised: March 11, 2016
Accepted: March 30, 2016
Article in press: March 30, 2016
Published online: April 28, 2016
Processing time: 76 Days and 10.3 Hours
Abstract

Severe gastrointestinal (GI) hemorrhage is a rare complication of Crohn’s disease (CD). Although several surgical and non-surgical approaches have been described over the last 2 decades this complication still poses significant diagnostic and therapeutic challenges. Given the relative infrequency of severe bleeding in CD, available medical literature on this topic is mostly in the form of retrospective case series and reports. In this article we review the risk factors, diagnostic modalities and treatment options for the management of CD presenting as GI hemorrhage.

Keywords: Crohn’s disease; Recurrence; Gastrointestinal hemorrhage; Biologic agents; Risk factors

Core tip: Severe gastrointestinal (GI) hemorrhage is a rare complication of Crohn’s disease (CD). With the relative infrequency of severe bleeding in CD, available medical literature on this topic is mostly in the form of retrospective case series and reports. In this article we reviewed the available medical literature and summarized the risk factors, diagnostic modalities and treatment options for the management of CD presenting as GI hemorrhage.