Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3355
Peer-review started: August 1, 2015
First decision: September 9, 2015
Revised: September 25, 2015
Accepted: December 12, 2015
Article in press: December 14, 2015
Published online: March 28, 2016
Processing time: 235 Days and 18.4 Hours
AIM: To present our initial experience regarding the feasibility of ultrasound virtual endoscopy (USVE) and its measurement reliability for polyp detection in an in vitro study using pig intestine specimens.
METHODS: Six porcine intestine specimens containing 30 synthetic polyps underwent USVE, computed tomography colonography (CTC) and optical colonoscopy (OC) for polyp detection. The polyp measurement defined as the maximum polyp diameter on two-dimensional (2D) multiplanar reformatted (MPR) planes was obtained by USVE, and the absolute measurement error was analyzed using the direct measurement as the reference standard.
RESULTS: USVE detected 29 (96.7%) of 30 polyps, remaining a 7-mm one missed. There was one false-positive finding. Twenty-six (89.7%) of 29 reconstructed images were clearly depicted, while 29 (96.7%) of 30 polyps were displayed on CTC with one false-negative finding. In OC, all the polyps were detected. The intraclass correlation coefficient was 0.876 (95%CI: 0.745-0.940) for measurements obtained with USVE. The pooled absolute measurement errors ± the standard deviations of the depicted polyps with actual sizes ≤ 5 mm, 6-9 mm, and ≥ 10 mm were 1.9 ± 0.8 mm, 0.9 ± 1.2 mm, and 1.0 ± 1.4 mm, respectively.
CONCLUSION: USVE is reliable for polyp detection and measurement in in vitro study.
Core tip: We present our initial experience regarding the feasibility of ultrasound virtual endoscopy (USVE) and its measurement reliability for polyp detection in an in vitro study using pig intestine specimens. USVE is a new technique that simulates views of computed tomography colonography (CTC). We found that USVE is an accurate screening method for simulated polyp detection and compares favorably to CTC and optical colonoscopy. As a dynamic, non-invasive, radiation-free, cost-effective method, USVE shows great promise for the screening and surveillance of colorectal cancers.