Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2793
Peer-review started: September 1, 2014
First decision: September 29, 2014
Revised: November 21, 2014
Accepted: December 19, 2014
Article in press: December 22, 2014
Published online: March 7, 2015
Processing time: 192 Days and 1.3 Hours
AIM: To compare the tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening with that of lugol chromoendoscopy.
METHODS: We prospectively enrolled and analyzed 51 patients who were at high risk for esophageal cancer. All patients were divided into two groups: a magnifying narrow band imaging group, and a lugol chromoendoscopy group, for comparison of adverse symptoms. Esophageal cancer screening was performed on withdrawal of the endoscope. The primary endpoint was a score on a visual analogue scale for heartburn after the examination. The secondary endpoints were scale scores for retrosternal pain and dyspnea after the examinations, change in vital signs, total procedure time, and esophageal observation time.
RESULTS: The scores for heartburn and retrosternal pain in the magnifying narrow band imaging group were significantly better than those in the lugol chromoendoscopy group (P = 0.004, 0.024, respectively, ANOVA for repeated measures). The increase in heart rate after the procedure was significantly greater in the lugol chromoendoscopy group. There was no significant difference between the two groups with respect to other vital sign. The total procedure time and esophageal observation time in the magnifying narrow band imaging group were significantly shorter than those in the lugol chromoendoscopy group (450 ± 116 vs 565 ± 174, P = 0.004, 44 ± 26 vs 151 ± 72, P < 0.001, respectively).
CONCLUSION: Magnifying narrow band imaging endoscopy reduced the adverse symptoms compared with lugol chromoendoscopy. Narrow band imaging endoscopy is useful and suitable for esophageal cancer screening periodically.
Core tip: We conducted prospective randomized study to determine whether magnifying narrow band imaging (NBI) endoscopy would reduce the adverse symptoms compared with lugol chromoendoscopy. Total, 51 patients who were at high risk for esophageal cancer were enrolled. All patients were divided into two groups for comparison of adverse symptoms. The visual analogue scale scores for heartburn and retrosternal pain in the magnifying NBI group were significantly better than those in the lugol chromoendoscopy group. Magnifying NBI endoscopy reduced the adverse symptoms compared with lugol chromoendoscopy. NBI endoscopy is very useful and suitable for screening esophageal cancer patients periodically.