Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2582
Peer-review started: October 4, 2014
First decision: October 29, 2014
Revised: November 15, 2014
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: March 7, 2015
Processing time: 156 Days and 14.9 Hours
Hepatosplanchnic circulation receives almost half of cardiac output and is essential to physiologic homeostasis. Liver cirrhosis is estimated to affect up to 1% of populations worldwide, including 1.5% to 3.3% of intensive care unit patients. Cirrhosis leads to hepatosplanchnic circulatory abnormalities and end-organ damage. Sepsis and cirrhosis result in similar circulatory changes and resultant multi-organ dysfunction. This review provides an overview of the hepatosplanchnic circulation in the healthy state and in cirrhosis, examines the signaling pathways that may play a role in the physiology of cirrhosis, discusses the physiology common to cirrhosis and sepsis, and reviews important issues in management.
Core tip: The prevalence of cirrhosis in critically ill patients is increasing worldwide. Cirrhosis leads to hepatosplanchnic circulatory abnormalities and end-organ damage, which resemble the clinical syndrome of patients with sepsis. The pathophysiology of cirrhosis can both predispose patients to, and exacerbate, sepsis. An understanding of this pathophysiology may assist critical care providers in the development and application of treatment modalities.