Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2015; 21(5): 1684-1688
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1684
Gastric metastasis from small cell lung cancer: A case report
Song Gao, Xu-Dong Hu, Su-Zhen Wang, Ning Liu, Wei Zhao, Qing-Xi Yu, Wen-Hong Hou, Shuang-Hu Yuan
Song Gao, Xu-Dong Hu, Su-Zhen Wang, Ning Liu, Wei Zhao, Qing-Xi Yu, Wen-Hong Hou, Shuang-Hu Yuan, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China
Author contributions: Yuan SH designed the report; Gao S, Wang SZ, Liu N and Yu QX performed the immunohistochemistry analyses; Gao S, Zhao W and Hou WH collected the patient’s clinical data; Gao S, Hu XD and Yuan S analyzed the data and wrote the paper.
Supported by Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shuang-Hu Yuan, MD, PhD, Professor, Department of Radiation Oncology, Shandong Cancer Hospital and Institute, School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, NO. 440 Jiyan Road, Jinan 250117, Shandong Province, China. yuanshuanghu@sina.com
Telephone: +86-531-67626931 Fax: +86-531-87984079
Received: August 16, 2014
Peer-review started: August 18, 2014
First decision: August 27, 2014
Revised: September 16, 2014
Accepted: October 21, 2014
Article in press: October 21, 2014
Published online: February 7, 2015
Abstract

Small cell lung cancer (SCLC) represents a group of highly malignant tumors that give rise to early and widespread metastases at the time of diagnosis. The preferential metastatic sites are the brain, liver, adrenal glands, bone, and bone marrow. However, metastases of the gastrointestinal system, especially the stomach, are rare; most cases of stomach metastasis are asymptomatic and, as a result, are usually only discovered at autopsy. We report a case of gastric metastasis originating from SCLC. The patient was a 66-year-old man admitted to our hospital due to abdominal pain. He underwent gastroscopy, with the pathological report of the tissue biopsy proving it to be a small cell cancer. Immunohistochemistry was positive for CD56, synaptophysin, and pan-cytokeratin. These results confirmed the diagnosis of gastric metastasis of a neuroendocrine small cell carcinoma from the lung.

Keywords: Gastric metastasis; Small cell lung cancer; Immunohistochemistry

Core tip: Small cell lung cancer metastases of the gastrointestinal system are rare; most cases of stomach metastasis are asymptomatic and as a result are usually only discovered at autopsy. We report a case of gastric metastasis originating from small cell lung cancer. The patient was a 66-year-old man admitted to our hospital due to abdominal pain and who underwent gastroscopy. The pathological report of the tissue biopsy proved it to be a small cell cancer, with immunohistochemistry being positive for CD56, synaptophysin, and pan-cytokeratin, thereby confirming the diagnosis of gastric metastasis of a neuroendocrine small cell carcinoma from the lung.