Haramura T, Haraguchi M, Irie J, Ito S, Tokai H, Noda K, Kitajima M, Minami S, Inoue K, Sasaki Y, Oshima K, Eguchi S. Case of plasmablastic lymphoma of the sigmoid colon and literature review. World J Gastroenterol 2015; 21(24): 7598-7603 [PMID: 26140010 DOI: 10.3748/wjg.v21.i24.7598]
Corresponding Author of This Article
Masashi Haraguchi, MD, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, 6-39 Shinchi-machi, Nagasaki 850-8555, Japan. haraguci@mb.ejnet.ne.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Tomoko Haramura, Masashi Haraguchi, Shinichiro Ito, Hirotaka Tokai, Kazumasa Noda, Masachika Kitajima, Shigeki Minami, Keiji Inoue, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan
Junji Irie, Department of Pathology, Nagasaki Harbor Medical Center City Hospital, Nagasaki 850-8555, Japan
Yuya Sasaki, Koichi Oshima, Department of Pathology, Kurume University, Fukuoka 830-0011, Japan
Susumu Eguchi, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan
Author contributions: Haraguchi M wrote the manuscript and organized the figures; Haramura T and Eguchi S assisted in writing the manuscript; Ito S, Tokai H, Noda K, Kitajima M, Minami S and Inoue K attended the patient; Irie J, Sasaki Y and Oshima K performed the pathological examination and provided the slides.
Conflict-of-interest: None of the authors have a conflict of interest related to the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Masashi Haraguchi, MD, Department of Surgery, Nagasaki Harbor Medical Center City Hospital, 6-39 Shinchi-machi, Nagasaki 850-8555, Japan. haraguci@mb.ejnet.ne.jp
Telephone: +81-95-8223251 Fax: +81-95-8268798
Received: December 8, 2014 Peer-review started: December 9, 2014 First decision: January 8, 2015 Revised: January 29, 2015 Accepted: February 11, 2015 Article in press: February 11, 2015 Published online: June 28, 2015 Processing time: 203 Days and 3.3 Hours
Abstract
Plasmablastic lymphoma (PBL) is a rare form of non-Hodgkin’s lymphoma that is associated with human immunodeficiency virus (HIV) infection. Although PBL is most commonly observed in the oral cavity of HIV-positive patients, it can also be observed at extra-oral sites in HIV-negative patients. This report represents an unusual case of HIV-negative PBL that occurred in the sigmoid colon. This patient had a history of systemic lupus erythematosus and an underlying immunosuppressive state from long term steroid therapy. The lymphoma cells were positive for CD138, kappa light chain restriction and Epstein-Barr virus and negative for CD20/L26, CD3, CD79a, UCHL1 (CD45RO) and cytokeratin (AE1/AE3). The patient died approximately 2 mo after the operation. In the present paper, we review cases of PBL of the colon in HIV-negative patients.
Core tip: Plasmablastic lymphoma (PBL) is a rare form of non-Hodgkin’s lymphoma that is associated with human immunodeficiency virus (HIV) infection. Although PBL is most commonly observed in the oral cavity of HIV-positive patients, it can also be observed at extra-oral sites in HIV-negative patients with an underlying immunosuppressive state. The gastrointestinal tract and skin are the most commonly involved extra-oral organ systems and cases of PBL in the colon are unusual. We report a case of HIV-negative PBL that occurred in the sigmoid colon.
