Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7495
Peer-review started: January 22, 2015
First decision: February 10, 2015
Revised: February 23, 2015
Accepted: April 16, 2015
Article in press: April 17, 2015
Published online: June 28, 2015
AIM: To determine the yield of biopsying normal duodenal mucosa for investigation of abdominal pain.
METHODS: This is a retrospective chart review of consecutive patients who underwent esophagogastroduodenoscopy (EGD) with duodenal biopsies of normal appearing duodenal mucosa for an indication that included abdominal pain. All the patients in this study were identified from an electronic endoscopy database at a single academic medical center and had an EGD with duodenal biopsies performed over a 4-year period. New diagnoses that were made as a direct result of duodenal biopsies were identified. All duodenal pathology reports and endoscopy records were reviewed for indications to perform the examination as well as the findings; all the medical records were reviewed. Exclusion criteria included age less than 18 years, duodenal mass, nodule, or polyp, endoscopic duodenitis, duodenal scalloping, known celiac disease, positive celiac serology, Crohns disease, or history of bone marrow transplant. Information was collected in a de-identified database with pertinent demographic information including human immunodeficiency virus (HIV) status, and descriptive statistics were performed.
RESULTS: About 300 patients underwent EGD with biopsies of benign appearing or normal appearing duodenal mucosa. The mean age of patients was 44.1 ± 16.8 years; 189 of 300 (63%) were female. A mean of 4.3 duodenal biopsies were performed in each patient. In the subgroup of patients with abdominal pain without anemia, diarrhea, or weight loss the mean age was 43.4 ± 16.3 years. Duodenal biopsies performed for an indication that included abdominal pain resulting in 4 new diagnoses (3 celiac disease and 1 giardiasis) for an overall yield of 1.3%. 183 patients with abdominal pain without anemia, diarrhea, or weight loss (out of the total 300 patients) underwent duodenal biopsy of duodenal mucosa resulting in three new diagnoses (two cases of celiac disease and one giardiasis) for a yield of 1.6%. Duodenal biopsies of 19 HIV patients presenting for evaluation of abdominal pain did not reveal any new diagnoses. Information pertaining to new diagnoses is provided.
CONCLUSION: Routine biopsy of normal appearing duodena in patients with abdominal pain should be reserved for those with a high pre-test probability given its low diagnostic yield.
Core tip: Duodenal biopsy is commonly performed, yet the diagnostic yield of routine duodenal biopsy of normal appearing duodenal mucosa for the evaluation of abdominal pain is unclear. This retrospective chart review of 300 consecutive patients with duodenal biopsy of normal appearing mucosa performed for evaluation of abdominal pain found a diagnostic yield of 1.3%. There were 3 new diagnoses of celiac disease and one of giardiasis. Routine biopsy of normal appearing duodenal mucosa during esophagogastroduodenoscopy should be reserved for patients with a high pretest probability of duodenal pathology given a low diagnostic yield.