Review
Copyright ©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Mar 7, 2014; 20(9): 2127-2135
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2127
Gender specific medicine in liver diseases: A point of view
Marilena Durazzo, Paola Belci, Alessandro Collo, Vanessa Prandi, Erika Pistone, Maria Martorana, Roberto Gambino, Simona Bo
Marilena Durazzo, Paola Belci, Alessandro Collo, Vanessa Prandi, Erika Pistone, Maria Martorana, Roberto Gambino, Simona Bo, Department of Medical Sciences, University of Turin, 10126 Turin, Italy
Author contributions: Durazzo M participated in the conception and design of the review, manuscript writing and revision; Belci P, Collo A, Prandi V, Pistone E, Martorana M, Gambino R and Bo S participated manuscript writing; all authors read and approved the final manuscript.
Correspondence to: Marilena Durazzo, Professor, Department of Medical Science, University of Turin, Corso A.M. Dogliotti 14, 10126 Turin, Italy. marilena.durazzo@unito.it
Telephone: +39-11-6336040   Fax: +39-11-6335401
Received: September 2, 2013
Revised: November 1, 2013
Accepted: December 5, 2013
Published online: March 7, 2014
Processing time: 184 Days and 17.7 Hours
Abstract

Gender medicine focuses on the patho-physiological, clinical, prevention and treatment differences in diseases that are equally represented in men and women. The purpose of gender medicine is to ensure that each individual man and woman receives the best treatment possible based on scientific evidence. The concept of “gender” includes not only the sexual characteristics of individuals but also physiological and psychological attributes of men and women, including risk factors, protective/aggravating effects of sexual hormones and variances linked to genetics and corporal structures that explain biological and physiological differences between men and women. It is very important to consider all the biological, physiological, functional, psychological, social and cultural characteristics to provide patients with individualized disease management. Herein, we critically analyze the literature regarding gender differences for diseases and acquired conditions of the most representative hepatic pathologies: primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis, non alcoholic fatty liver disease and alcoholic liver disease, and viral chronic hepatitis B and C. The last section addresses hemochromatosis, which is a prevalent iron overload disorder in the Caucasian population. This review aims to describe data from the literature concerning viral chronic hepatitis during pregnancy, management during pregnancy and delivery, and new effective drugs for the prevention of maternal infection transmission without significant adverse effects or complications.

Keywords: Gender; Liver disease; Primary biliary cirrhosis; Autoimmune hepatitis; Viral chronic hepatitis B; Viral chronic hepatitis C; Non alcoholic fatty liver disease; Alcoholic liver disease

Core tip: Gender medicine focuses on the patho-physiological, clinical, prevention and treatment differences in diseases that are equally represented in men and women. The concept of “gender” includes not only the sexual characteristics of individuals but also physiological and psychological attributes of men and women. In this review, we critically analyze the literature regarding gender differences for diseases and acquired conditions of the most representative hepatic pathologies: primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis, non alcoholic fatty liver disease and alcoholic liver disease, viral chronic hepatitis B and C, and hemochromatosis (the prevalent iron overload disorder in the Caucasian population).