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World J Gastroenterol. Feb 21, 2014; 20(7): 1667-1680
Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1667
Role of the tumor microenvironment in the pathogenesis of gastric carcinoma
Hye Won Chung, Jong-Baeck Lim
Hye Won Chung, Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 135-720, South Korea
Jong-Baeck Lim, Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul 135-720, South Korea
Author contributions: Chung HY and Lim JB designed the research; Chung HY and Lim JB performed research and analyzed the the data; and Chung HY and Lim JB wrote the paper.
Correspondence to: Jong-Baeck Lim, MD, PhD, Associate Professor, Department of Laboratory Medicine, Yonsei University College of Medicine, 50 Seodaemun-gu Seoul 135-720, South Korea. jlim@yuhs.ac
Telephone: +82-2-20193533 Fax: +82-2-20578926
Received: October 28, 2013
Revised: November 22, 2013
Accepted: December 5, 2013
Published online: February 21, 2014
Processing time: 134 Days and 17.6 Hours
Abstract

Gastric carcinoma (GC) is the 4th most prevalent cancer and has the 2nd highest cancer-related mortality rate worldwide. Despite the incidence of GC has decreased over the past few decades, it is still a serious health problem. Chronic inflammatory status of the stomach, caused by the infection of Helicobacter pylori (H. pylori) and through the production of inflammatory mediators within the parenchyma is suspected to play an important role in the initiation and progression of GC. In this review, the correlation between chronic inflammation and H. pylori infection as an important factor for the development of GC will be discussed. Major components, including tumor-associated macrophages, lymphocytes, cancer-associated fibroblasts, angiogenic factors, cytokines, and chemokines of GC microenvironment and their mechanism of action on signaling pathways will also be discussed. Increasing our understanding of how the components of the tumor microenviroment interact with GC cells and the signaling pathways involved could help identify new therapeutic and chemopreventive targets.

Keywords: Tumor microenvironment; Gastric carcinoma; Inflammation; Helicobacter pylori; Cytokine

Core tip: The intensive interplay that exists between tumor cells and the tumor microenvironment can play an important role in tumor initiation, growth and metastasis. A better understanding of the molecular pathogenesis of the tumor microenvironment of Gastric carcinoma would be crucial for the design of novel molecular targets. In this review, we have provided an overview of the currently available knowledge of the role of the TME in gastric cancer and have highlighted the potential prognostic and therapeutic implications.