Case Report
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World J Gastroenterol. Dec 14, 2014; 20(46): 17661-17665
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17661
Rare combination of familial adenomatous polyposis and gallbladder polyps
Yasuhisa Mori, Norihiro Sato, Nobutaka Matayoshi, Toshihisa Tamura, Noritaka Minagawa, Kazunori Shibao, Aiichiro Higure, Mitsuhiro Nakamoto, Masashi Taguchi, Koji Yamaguchi
Yasuhisa Mori, Norihiro Sato, Nobutaka Matayoshi, Toshihisa Tamura, Noritaka Minagawa, Kazunori Shibao, Aiichiro Higure, Koji Yamaguchi, Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807-8555, Japan
Mitsuhiro Nakamoto, Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807-8555, Japan
Masashi Taguchi, Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807-8555, Japan
Author contributions: Nakamoto M conceived of and designed the manuscript; Taguchi M and Yamaguchi K approved the treatments; Mori Y performed the majority of this study and drafted the manuscript; Sato N, Matayoshi N, Tamura T, Minagawa N, Shibao K and Higure A contributed to the writing of the article.
Correspondence to: Koji Yamaguchi, MD, PhD, Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 807-8555, Japan. yamaguch@med.uoeh-u.ac.jp
Telephone: +81-93-6031611 Fax: +81-93-6032361
Received: February 26, 2014
Revised: July 28, 2014
Accepted: August 13, 2014
Published online: December 14, 2014
Processing time: 112 Days and 8.3 Hours
Abstract

Familial adenomatous polyposis is associated with a high incidence of malignancies in the upper gastrointestinal tract (particularly ampullary adenocarcinomas). However, few reports have described a correlation between familial adenomatous polyposis and gallbladder neoplasms. We present a case of a 60-year-old woman with familial adenomatous polyposis who presented with an elevated mass in the neck of the gallbladder (measuring 16 mm × 8 mm in diameter) and multiple small cholecystic polyps. She had undergone a total colectomy for ascending colon cancer associated with familial adenomatous polyposis 22 years previously. The patient underwent laparoscopic cholecystectomy under a preoperative diagnosis of multifocal gallbladder polyps. Pathologic examination of the resected gallbladder revealed more than 70 adenomatous lesions, a feature consistent with adenoma of the gallbladder. This case suggests a requirement for long-term surveillance of the biliary system in addition to the gastrointestinal tract in patients with familial adenomatous polyposis.

Keywords: Adenoma; Adenomatous polyposis coli; Biliary system; Familial adenomatous polyposis; Gallbladder polyp

Core tip: Familial adenomatous polyposis (FAP) is associated with a high incidence of malignancies in the upper gastrointestinal tract. However, few reports have described a correlation between FAP and gallbladder neoplasms. This case, along with the other previously reported cases of FAP-associated extraintestinal neoplasia, suggests a requirement for long-term surveillance of the biliary system in addition to the gastrointestinal tract in patients with FAP.