Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17635
Revised: July 19, 2014
Accepted: September 5, 2014
Published online: December 14, 2014
Processing time: 203 Days and 11.7 Hours
AIM: To review and conduct a meta-analysis of the existing literature on the relationship between Helicobacter pylori (H. pylori), atopy and allergic diseases.
METHODS: Studies published in English assessing the prevalence of atopy and/or allergic diseases in patients with H. pylori infection and the prevalence of H. pylori infection in patients with atopy and/or allergic diseases were identified through a MEDLINE search (1950-2014). Random-effect model was used for the meta-analysis.
RESULTS: Pooled results of case-control studies showed a significant inverse association of H. pylori infection with atopy/allergic disease or with exclusively atopy, but not with allergic disease, whereas pooled results of cross-sectional studies showed only a significant association between allergic disease and H. pylori infection.
CONCLUSION: There is some evidence of an inverse association between atopy/allergic diseases and H. pylori infection, although further studied are needed.
Core tip: As the hygiene hypothesis affirms, the most important factor connected with the large spreading of atopic disease is the decreased exposure to food born and oro-fecal infections, including Helicobacter pylori (H. pylori) infection, due to the improvement of hygienic condition occurred in developed countries. The aim of this article was to review and conduct a meta-analysis of the existing literature on the relationship between H. pylori, atopy and allergic diseases. There is some evidence of an inverse association between atopy/allergic diseases and H. pylori infection, although further studied are needed.