Lu BC, Wang C, Yu JH, Shen ZH, Yang JH. A huge adenosquamous carcinoma of the pancreas with sarcomatoid change: An unusual case report. World J Gastroenterol 2014; 20(43): 16381-16386 [PMID: 25473201 DOI: 10.3748/wjg.v20.i43.16381]
Corresponding Author of This Article
Bao-Chun Lu, MD, Department of General Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, 568 Zhongxing Road, Shaoxing 312000, Zhejiang Province, China. sygd_lbc@126.com
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 21, 2014; 20(43): 16381-16386 Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16381
A huge adenosquamous carcinoma of the pancreas with sarcomatoid change: An unusual case report
Bao-Chun Lu, Chen Wang, Jian-Hua Yu, Zhi-Hong Shen, Jian-Hui Yang
Bao-Chun Lu, Jian-Hua Yu, Zhi-Hong Shen, Jian-Hui Yang, Department of General Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China
Chen Wang, Department of Pathology, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang Province, China
Author contributions: Lu BC designed research; Wang C performed operation of pathology; Yu JH analyzed data and wrote the paper; Shen ZH and Yang JH looked after the patient; Lu BC and Wang C contributed equally to this manuscript.
Supported by Research Foundation of Health Bureau of Zhejiang Province, China, No. 2013RCB018; and Public Technology Research and Social Development Project of Zhejiang Province, China, No. 2013C33214
Correspondence to: Bao-Chun Lu, MD, Department of General Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, 568 Zhongxing Road, Shaoxing 312000, Zhejiang Province, China. sygd_lbc@126.com
Telephone: +86-575-88228828 Fax: +86-575-85138402
Received: April 10, 2014 Revised: June 19, 2014 Accepted: July 16, 2014 Published online: November 21, 2014 Processing time: 223 Days and 22.9 Hours
Abstract
Adenosquamous carcinoma rarely occurs in the pancreas, and is characterized by the presence of cellular components from both duct adenocarcinoma and squamous carcinoma. Here, we describe a rare case of pancreatic adenosquamous carcinoma with sarcomatous change. Immunohistochemistry showed that the sarcomatous lesion lost the epithelial marker and aberrantly expressed of acquired mesenchymal markers, which indicated that this special histological phenotype may be attributed to epithelial-mesenchymal transition. This case also indicated that a routine radical surgery without aggressive treatment strategies was still appropriate for adenosquamous carcinoma of the pancreas with sarcomatoid change.
Core tip: Adenosquamous carcinoma rarely occurs in the pancreas, and is characterized by the presence of cellular components from both duct adenocarcinoma and squamous carcinoma.
