Wei XQ, Zheng ZH, Jin Y, Tao J, Abassa KK, Wen ZF, Shao CK, Wei HB, Wu B. Intestinal obstruction caused by extramedullary hematopoiesis and ascites in primary myelofibrosis. World J Gastroenterol 2014; 20(33): 11921-11926 [PMID: 25206301 DOI: 10.3748/wjg.v20.i33.11921]
Corresponding Author of This Article
Bin Wu, MD, PhD, Professor, Chief, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road No. 600, Tianhe district, Guangzhou 510630, Guangdong Province, China. binwu001@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 7, 2014; 20(33): 11921-11926 Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11921
Intestinal obstruction caused by extramedullary hematopoiesis and ascites in primary myelofibrosis
Xiu-Qing Wei, Zong-Heng Zheng, Yi Jin, Jin Tao, Kodjo-Kunale Abassa, Zhuo-Fu Wen, Chun-Kui Shao, Hong-Bo Wei, Bin Wu
Xiu-Qing Wei, Jin Tao, Kodjo-Kunale Abassa, Zhuo-Fu Wen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China
Zong-Heng Zheng, Hong-Bo Wei, Department of Gastrointestinal Surgery, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China
Yi Jin, Chun-Kui Shao, Department of Pathology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China
Author contributions: Wei XQ and Zheng ZH contributed equally to this work; Wei XQ, Zheng ZH, Jin Y, Tao J, Abassa KK, Wen ZF, Shao CK, Wei HB and Wu B analyzed the data and diagnosed and treated the patient; Wei XQ and Wu B wrote the paper.
Supported by National Natural Science Foundation of China, No. 81272640; Guangdong Science and Technology Program, No. 2010B031200008 and No. 2012B031800043
Correspondence to: Bin Wu, MD, PhD, Professor, Chief, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road No. 600, Tianhe district, Guangzhou 510630, Guangdong Province, China. binwu001@hotmail.com
Telephone: +86-20-85253095 Fax: +86-20-85253336
Received: January 14, 2014 Revised: March 18, 2014 Accepted: May 23, 2014 Published online: September 7, 2014 Processing time: 236 Days and 1.7 Hours
Abstract
Primary myelofibrosis (PMF) is a clonal hematopoietic stem cell disorder. It is characterized by bone marrow fibrosis, extramedullary hematopoiesis with hepatosplenomegaly and leukoerythroblastosis in the peripheral blood. The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever. Here we report a rare case of PMF with anemia, small bowel obstruction and ascites due to extramedullary hematopoiesis and portal hypertension. The diagnosis was difficult to establish before surgery and the differential diagnosis is discussed.
Core tip: Bowel obstruction caused by extramedullary hematopoiesis and ascites due to portal hypertension are uncommon symptoms in primary myelofibrosis. Physicians should bear in mind that these rare manifestations can occur at the same time in a single patient.
