Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10637
Revised: January 26, 2014
Accepted: April 30, 2014
Published online: August 14, 2014
Splenic hamartoma (SH) is a rare benign tumor usually detected accidentally, which is composed of an aberrant mixture of normal splenic elements. Here, we report a case of 54-year-old man who presented with symptomatic multinodular SH and was admitted initially for thrombocytopenia and anemia. Physical examination revealed that the patients had an anemic appearance and palpable spleen, extending 10 cm below the costal margin. Preoperative ultrasound and computed tomography (CT) indicated splenomegaly with multinodular lesions. On enhanced CT scanning, during the arterial phase, the lesions demonstrated inhomogeneous enhancement, and in the portal phase the lesions were more hyperdense than the splenic parenchyma. The images were highly suggestive of a metastatic tumor. Splenectomy was performed 1 wk later. The tumor was eventually diagnosed as SH according to the morphological features and immunohistochemical detection, by which CD34 was positive in lining cells and some spindle cells, vimentin was positive in the tumor, factor-VIII-related antigen was positive multifocally in lining cells, and smooth muscle actin was positive in some spindle cells. Thrombocytopenia and anemia were cured after splenectomy.
Core tip: Splenic hamartoma (SH) is a rare benign tumor that is usually detected accidentally. This case represents one of the largest SHs reported in the literature, and we report the use of immunohistochemistry as a tool to confirm the diagnosis. Thrombocytopenia and anemia were cured after splenectomy.