Irritable bowel syndrome: A concise review of current treatment concepts

doi:10.3748/wjg.v20.i27.8796

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2014; 20(27): 8796-8806
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8796

Irritable bowel syndrome: A concise review of current treatment concepts

Geoffrey C Wall, Ginelle A Bryant, Michelle M Bottenberg, Erik D Maki, Andrew R Miesner

Geoffrey C Wall, Ginelle A Bryant, Michelle M Bottenberg, Erik D Maki, Andrew R Miesner, Department of Pharmacy Practice, Drake University College of Pharmacy, Des Moines, IA 50311, United States

Author contributions: All authors participated in literature review, retrieval, synthesis as well as writing this paper

Correspondence to: Geoffrey C Wall, Pharm.D., FCCP, BCPS, CGP, Department of Pharmacy Practice, Drake University College of Pharmacy, 2507 University Ave., Des Moines, IA 50311, United States. geoff.wall@drake.edu

Telephone: +1-515-2414297 Fax: +1-515-2415085

Received: September 27, 2013
Revised: March 4, 2014
Accepted: June 14, 2014
Published online: July 21, 2014
Processing time: 296 Days and 19.7 Hours

Abstract

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders causing patients to seek medical treatment. It is relatively resource intensive and the source of significant morbidity. Recent insights into the pathophysiology and treatment of IBS has given clinicians more options than ever to contend with this disorder. The purpose of our paper is to review older, “classic” treatments for IBS as well as newer agents and “alternative” therapies. We discuss the evidence base of these drugs and provide context to help develop appropriate treatment plans for IBS patients.

Keywords: Irritable bowel syndrome; Probiotics; Rifaximin; Lubiprostone; Linaclotide; Peppermint oil

Core tip: Gastroenterology practitioners have more agents than ever before to treat the symptoms associated with irritable bowel syndrome. Unfortunately, despite advances in our understanding of the pathophysiology of this disorder, targeted treatments do not yet exist. This review summarizes the recent evidence-based treatment of this disorder, including, older and newer agents.