Clinical Trials Study
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World J Gastroenterol. May 7, 2014; 20(17): 5087-5091
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.5087
Value of a new stick-type rapid urine test for the diagnosis of Helicobacter pylori infection in the Vietnamese population
Duc T Quach, Toru Hiyama, Fumio Shimamoto, Quang D Le, Linh X Ho, Nhu HT Vu, Masaharu Yoshihara, Naomi Uemura
Duc T Quach, Quang D Le, Nhu HT Vu, Department of Endoscopy, University Medical Center, Ho Chi Minh 70000, Vietnam
Toru Hiyama, Masaharu Yoshihara, Health Service Center, Hiroshima University, Higashihiroshima 739-8514, Japan
Fumio Shimamoto, Faculty of Human Culture and Science, Prefectural University of Hiroshima, Hiroshima 734-8558, Japan
Linh X Ho, Department of Gastroenterology, Gia-Dinh People’s Hospital, Ho Chi Minh 70000, Vietnam
Naomi Uemura, Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Ichikawa 272-8516, Japan
Author contributions: Quach DT and Hiyama T designed the research, analyzed data statistically and wrote the paper; Quach DT, Le QD, Ho LX and Vu NH collected the samples; Shimamoto F diagnosed the presence of H. pylori pathologically; Yoshihara M and Uemura N supervised the research.
Supported by International Collaborative Research Grant of the Japanese Society of Gastrointestinal Cancer Screening
Correspondence to: Dr. Duc T Quach, Department of Endoscopy, University Medical Center, 215 Hong Bang Street, District 5, Ho Chi Minh 70000, Vietnam. drquachtd@ump.edu.vn
Telephone: +84-8-38554269 Fax: +84-8-39506126
Received: November 28, 2013
Revised: February 22, 2014
Accepted: March 4, 2014
Published online: May 7, 2014
Processing time: 159 Days and 10.7 Hours
Abstract

AIM: To assess the value of a new test for the diagnosis of Helicobacter pylori (H. pylori) infection, Rapirun®H. pylori Antibody Stick (Rapirun® Stick), in a Vietnamese population.

METHODS: Eligible patients without previous history of H. pylori eradication were recruited. Rapid urease test (RUT) and histologic examination were used to diagnose the H. pylori infection. Patients were considered H. pylori positive when the RUT results were positive and/or the bacteria were detected histologically. Rapirun® Stick tests were performed using urine samples, and the results were compared with the other 2 methods.

RESULTS: We enrolled 200 patients with a mean age of 36 (range, 18-76) years. There were 116 females and 84 males. Of the 200 patients, 111 (55.5%) were diagnosed as being H. pylori positive. The sensitivity, specificity, and accuracy of the Stick test were 84.7%, 89.9%, and 87.0%, respectively. There were 17 (8.5%) false-negative patients and 9 (4.5%) false-positive patients.

CONCLUSION: The Rapirun® Stick test has high sensitivity, specificity, and accuracy for the diagnosis of H. pylori infection in the Vietnamese population. The test can be clinically applied in Vietnamese populations.

Keywords: Helicobacter pylori; Urine test; Rapirun® Stick; Vietnamese; Rapid urease test

Core tip: The Rapirun®Helicobacter pylori (H. pylori) Antibody Stick (Rapirun® Stick) has recently been developed to detect anti-H. pylori antibody in urine. This test requires fewer processing steps and provides quicker results. This study attempted to assess the value of this new test for the diagnosis of H. pylori infection in a Vietnamese population. The sensitivity, specificity, and accuracy of the Stick test were 84.7%, 89.9%, and 87.0%, respectively. The Rapirun® Stick test has high sensitivity, specificity, and accuracy for the diagnosis of H. pylori infection in the Vietnamese population. The test can be clinically applied in Vietnamese populations.