Changes of neurotensin and endotoxin in rats with intestinal ischemia

doi:10.3748/wjg.v2.i4.200

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 15, 1996; 2(4): 200-202
Published online Dec 15, 1996. doi: 10.3748/wjg.v2.i4.200

Changes of neurotensin and endotoxin in rats with intestinal ischemia

Can-Ping Ruan, Yuan-He Wang, Lai-Gen Wang, Yi-Xin Wang

Can-Ping Ruan, Yuan-He Wang, Lai-Gen Wang, Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

Can-Ping Ruan, Surgeon-in-Charge, having 7 papers published

Yi-Xin Wang, Chinese PLA Navy 408 Hospital, Shanghai 200003, China

Author contributions: All authors contributed equally to the work.

Supported by Military Science Foundation of Chinese PLA, No. 02006-2.

Correspondence to: Dr. Can-Ping Ruan, Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

Telephone: +83-21-63275997-386

Received: July 12, 1996
Revised: August 26, 1996
Accepted: October 25, 1996
Published online: December 15, 1996

Abstract

AIM: To investigate the changes of neurotensin (NT) and endotoxin in rats with segmental intestinal ischemia.

METHODS: The distal ileal mesenteric arteries in rats were ligated to make segmental intestinal ischemia models. At the 2^nd, 6^th and 12^th hours after intestinal ischemia, endotoxin levels in portal blood were tested by limulus lysate test and NT levels in plasma from the heart and in intestine tissues (ischemia and peri-ischemia areas) were assayed by radioimmunoassay. Histological changes of the mucosa were examined under light and electron microscopes.

RESULTS: NT levels decreased significantly in intestinal ischemia and peri-ischemia areas (34.07 ± 5.93 vs 40.14 ± 5.38, P < 0.05; 7.47 ± 1.38 vs 40.14 ± 5.38, P < 0.01), especially lower in ischemia area (34.07 ± 5.93 vs 7.47 ± 1.38, P < 0.05. However, NT level increased obviously in plasma (0.76 ± 0.16 vs 0.47 ± 0.10, P < 0.05). Levels of endotoxin elevated obviously in portal blood (389.0 ± 105.0 vs 55.1 ± 6.7, P < 0.01), and the mucosa was injured both in ischemia and peri-ischemia areas.

CONCLUSION: Intestinal ischemia injures intestinal mucosa and leads to decrease of intestinal NT level, which is accelerated by endotoxemia and increase of blood NT level.

Keywords: Neurotensin; Endotoxin; Intestinal ischemia