Han GA, Jiang HM, Zhen XM, Zhou HJ, Xu CZ, Tian JX. Protective action of various doses of compound zinc preparation on cadmium-induced liver damage. World J Gastroenterol 1996; 2(4): 190-191 [DOI: 10.3748/wjg.v2.i4.190]
Corresponding Author of This Article
Dr. Guo-An Han, Assistant Professor, Department of Analytical Chemistry, Pharmacy Faculty, Shandong Medical University, Jinan 250012, Shandong Province, China
Article-Type of This Article
Experimental Papers
Open-Access Policy of This Article
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Guo-An Han, Department of Analytical Chemistry, Pharmacy Faculty, Shandong Medical University, Jinan 250012, Shandong Province, China
Hui-Min Jiang, Department of Hygenic Chemistry, Shandong Medical University, Jinan 250012, Shandong Province, China
Xiu-Mei Zhen, Jinan Railway Central Hospital, Jinan 250012, Shandong Province, China
Hong-Jun Zhou, Department of Biomedical Engineering, Jinan 250012, Shandong Province, China
Cai-Zhen Xu, Ji-Xi Tian, Department of pathological Anatomy, Jinan 250012, Shandong Province, China
Guo-An Han, Assistant Professor, Born in 1939-08-15, Qixia, Shandong Province, and graduated in 1966 from Shandong University, primarily engaged in research of the relationship between trace elements and diseases, having 33 papers published and the progect “the interference of trace elements in Cadmium induced malformation and study of clinical practice”, having received the second award of scientific and technical progress by science and technology committees Shandong, in 1995
Author contributions: All authors contributed equally to the work.
Supported by Project of Shandong Provincial Science and Technology Committee in 1990, No. 95-2-48-2.
Correspondence to: Dr. Guo-An Han, Assistant Professor, Department of Analytical Chemistry, Pharmacy Faculty, Shandong Medical University, Jinan 250012, Shandong Province, China
Received: July 26, 1996 Revised: August 15, 1996 Accepted: October 10, 1996 Published online: December 15, 1996
Abstract
AIM: To investigate the protective action of various doses of compound zinc (Zn) preparation on liver damages induced by cadmium (Cd) in pregnant rats.
METHODS: The changes in the microstructure and ultrastructure of hepatic cells were observed by microscopy and electron microscopy.
RESULTS: In Cd-toxic group, severe damage of hepatic cells was observed. Electron microscopic analysis showed extensive irreversible pathological changes, such as nearly dissolved hepatic cells with a lot of vacuoles, swelling endoplasmic reticulum and partial degeneration of mitochondrial cristae. However, in 300 μg/mL Zn group, the microstructure and ultrastructure were normal.
CONCLUSION: Zn has a remarkable protective effect on the Cd-induced hepatic cell damage in pregnant rats, and the effect is dose-dependent. Zn at a dose of 300 μg/mL has a significant protective action.
