Brief Article
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World J Gastroenterol. Aug 21, 2013; 19(31): 5103-5110
Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5103
Colonic preparation before colonoscopy in constipated and non-constipated patients: A randomized study
Lisandro Pereyra, Daniel Cimmino, Carlos González Malla, Mariano Laporte, Nicolás Rotholtz, Carlos Peczan, Sandra Lencinas, Silvia Pedreira, Hugo Catalano, Luis Boerr
Lisandro Pereyra, Daniel Cimmino, Mariano Laporte, Nicolás Rotholtz, Carlos Peczan, Sandra Lencinas, Silvia Pedreira, Luis Boerr, Department of Endoscopy, Hospital Alemán, 1118 Buenos Aires, Argentina
Carlos González Malla, Hugo Catalano, Department of Internal Medicine, Hospital Alemán, 1118 Buenos Aires, Argentina
Mariano Laporte, Nicolás Rotholtz, Carlos Peczan, Sandra Lencinas, Department of Surgery, Hospital Alemán, 1118 Buenos Aires, Argentina
Author contributions: Pereyra L, Cimmino D and González Malla C designed the study protocol; González Malla C, Pedreira S and Boerr L performed randomization; González Malla C analysed data; Cimmino D, Laporte M, Rotholtz N, Peczan C and Lencinas S performed colonoscopies and evaluated colonic cleansing quality; Pereyra L, González Malla C and Catalano H wrote the paper.
Correspondence to: Lisandro Pereyra, MD, Department of Endoscopy, Hospital Alemán, Pueyrredon Avenue 1640, 1118 Buenos Aires, Argentina. lisandro_pereyra@hotmail.com
Telephone: +54-11-4827700 Fax: +54-11-48277000
Received: September 14, 2012
Revised: February 8, 2013
Accepted: March 15, 2013
Published online: August 21, 2013
Processing time: 340 Days and 1.2 Hours
Abstract

AIM: To compare the efficacy of different doses of sodium phosphate (NaP) and polyethylenglicol (PEG) alone or with bisacodyl for colonic cleansing in constipated and non-constipated patients.

METHODS: Three hundred and forty-nine patients, older than 18 years old, with low risk for renal damage and who were scheduled for outpatient colonoscopy were randomized to receive one of the following preparations (prep): 90 mL of NaP (prep 1); 45 mL of NaP + 20 mg of bisacodyl (prep 2); 4 L of PEG (prep 3) or 2 L of PEG + 20 mg of bisacodyl (prep 4). Randomization was stratified by constipation. Patients, endoscopists, endoscopists’ assistants and data analysts were blinded. A blinding challenge was performed to endoscopist in order to reassure blinding. The primary outcome was the efficacy of colonic cleansing using a previous reported scale. Secondary outcomes were tolerability, compliance, side effects, endoscopist perception about the necessity to repeat the study due to an inadequate colonic preparation and patient overall perceptions.

RESULTS: Information about the primary outcome was obtained from 324 patients (93%). There were no significant differences regarding the preparation quality among different groups in the overall analysis. Compliance was higher in the NaP preparations being even higher in half-dose with bisacodyl: 94% (prep 1), 100% (prep 2), 81% (prep 3) and 87% (prep 4) (2 vs 1, 3 and 4, P < 0.01; 1 vs 3, 4, P < 0.05). The combination of bisacodyl with NaP was associated with insomnia (P = 0.04). In non-constipated patients the preparation quality was also similar between different groups, but endoscopist appraisal about the need to repeat the study was more frequent in the half-dose PEG plus bisacodyl than in whole dose NaP preparation: 11% (prep 4) vs 2% (prep 1) (P < 0.05). Compliance in this group was also higher with the NaP preparations: 95% (prep 1), 100% (prep2) vs 80% (prep 3) (P < 0.05). Bisacodyl was associated with abdominal pain: 13% (prep 1), 31% (prep 2), 21% (prep 3) and 29% (prep 4), (2, 4 vs 1, 2, P < 0.05). In constipated patients the combination of NaP plus bisacodyl presented higher rates of satisfactory colonic cleansing than whole those PEG: 95% (prep 2) vs 66% (prep 3) (P = 0.03). Preparations containing bisacodyl were not associated with adverse effects in constipated patients.

CONCLUSION: In non-constipated patients, compliance is higher with NaP preparations, and bisacodyl is related to adverse effects. In constipated patients NaP plus bisacodyl is the most effective preparation.

Keywords: Colonic cleansing; Sodium phosphate; Polyethylenglicol; Bisacodyl constipation; Colonoscopy

Core tip: Colonoscopy has become the standard procedure for the diagnosis and treatment of colon diseases. Adequate bowel cleansing is essential for a high-quality effective and safe colonoscopy. In non-constipated patients, compliance is higher with sodium phosphate (NaP) preparations, and bisacodyl is related to adverse effects. In constipated patients NaP plus bisacodyl is the most effective preparation.