Expression of huCdc7 in colorectal cancer

doi:10.3748/wjg.v19.i20.3130

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May 28, 2013 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2013; 19(20): 3130-3133
Published online May 28, 2013. doi: 10.3748/wjg.v19.i20.3130

Expression of huCdc7 in colorectal cancer

Hai-Jun Chen, Zhen Zhu, Xue-Lin Wang, Quan-Lin Feng, Qing Wu, Zheng-Ping Xu, Jiang Wu, Xiao-Feng Yu, Hong-Liang Qian, Qi Lu

Hai-Jun Chen, Zhen Zhu, Xue-Lin Wang, Quan-Lin Feng, Qing Wu, Zheng-Ping Xu, Jiang Wu, Xiao-Feng Yu, Hong-Liang Qian, Qi Lu, Department of Oncology, Kunshan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Kunshan 215300, Jiangsu Province, China

Author contributions: Chen HJ, Zhu Z and Lu Q designed the research; Wang XL, Feng QL, Wu Q, Xu ZP and Wu J performed research; Chen HJ, Yu XF, Qian HL and Lu Q analyzed the data; all the authors contributed to the preparation of the manuscript.

Correspondence to: Dr. Hai-Jun Chen, Department of Oncology, Kunshan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, No. 189 Chaoyang Road, Kunshan 215300, Jiangsu Province, China. ksschj@126.com

Telephone: +86-512-57310000 Fax: +86-512-57928140

Received: March 7, 2013
Revised: March 29, 2013
Accepted: April 3, 2013
Published online: May 28, 2013
Processing time: 82 Days and 0.4 Hours

Abstract

AIM: To detect the expression of huCdc7 in colorectal cancer.

METHODS: The mRNA and protein expression of huCdc7 in 39 colorectal cancer tissue specimens and matched tumor-adjacent normal colorectal tissue specimens was detected by reverse transcription-polymerase chain reaction and immunohistochemistry, respectively.

RESULTS: The relative expression level of huCdc7 mRNA in colorectal cancer was significantly higher than that in tumor-adjacent normal colorectal tissues (0.03675 ± 1.00 vs 0.01199 ± 0.44, P < 0.05). huCdc7-positive cells displayed brown granules in the nucleus. Tumor tissues contained many huCdc7-positive cells, whereas normal colorectal tissues contained very few positive cells.

CONCLUSION: huCdc7 may play an important role in the development and progression of colorectal cancer.

Keywords: huCdc7; Semiquantitative reverse transcription-polymerase chain reaction; Colorectal cancer

Core tip: huCdc7 is ubiquitously expressed in human tissues and can regulate DNA replication initiation. Abnormal expression or excessive activation of huCdc7 can promote excessive cell proliferation and cause tumorigenesis. Colorectal cancer is a common digestive tract tumor with a gradually increasing incidence. We found that huCdc7 may play an important role in the development and progression of colorectal cancer.