Miyazaki H, Takabe K, Yeudall WA. Chemokines, chemokine receptors and the gastrointestinal system. World J Gastroenterol 2013; 19(19): 2847-2863 [PMID: 23704819 DOI: 10.3748/wjg.v19.i19.2847]
Corresponding Author of This Article
Hiroshi Miyazaki, MD, PhD, Assistant Professor, Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University School of Dentistry, PO Box 980566, 520 N 12th St, Richmond, VA 23298, United States. hmiyazaki@vcu.edu
Research Domain of This Article
Oncology
Article-Type of This Article
Review
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World J Gastroenterol. May 21, 2013; 19(19): 2847-2863 Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2847
Chemokines, chemokine receptors and the gastrointestinal system
Hiroshi Miyazaki, Kazuaki Takabe, W Andrew Yeudall
Hiroshi Miyazaki, Kazuaki Takabe, W Andrew Yeudall, Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, United States
Hiroshi Miyazaki, W Andrew Yeudall, Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, United States
Hiroshi Miyazaki, W Andrew Yeudall, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, United States
Kazuaki Takabe, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298, United States
Author contributions: All the authors generated the ideas and contributed to the writing of this paper.
Correspondence to: Hiroshi Miyazaki, MD, PhD, Assistant Professor, Philips Institute of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University School of Dentistry, PO Box 980566, 520 N 12th St, Richmond, VA 23298, United States. hmiyazaki@vcu.edu
Telephone: +1-804-8271766 Fax: +1-804-8280150
Received: September 12, 2012 Revised: March 22, 2013 Accepted: April 27, 2013 Published online: May 21, 2013 Processing time: 270 Days and 1.8 Hours
Abstract
The biological properties of tumor cells are known to be regulated by a multitude of cytokines and growth factors, which include epidermal growth factor receptor agonists and members of the transforming growth factor β family. Furthermore, the recent explosion of research in the field of chemokine function as mediators of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches. In this review, we will summarize recently reported findings in chemokine biology with a focus on the gastrointestinal tract.
Core tip: The chemokine network makes an attractive target for therapeutic intervention in many tumor types, including those of the gastrointestinal tract. However, we need to define more selective and specific targets, to minimize systemic side effects during treatment.
